Fatty acids, C18-unsatd., phosphates

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

6th July 2017- 12th October 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

Water Solubility: Column Elution Method; Shake Flask Method. March 1998.

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 0101891886
- Expiration date of the lot/batch: 02 November 2017

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: Not indicated

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
Test item dosing formulations (w/w) were homogenized to visually acceptable levels at appropriate concentrations to meet dose level requirements.

Water solubility:

206 g/L

Conc. based on:

test mat. (dissolved fraction)

Temp.:

20 °C

pH:

1.4

Remarks on result:

other: Solubility of Dimethyl-n-propylphosphonate

Water solubility:

0.024 g/L

Conc. based on:

test mat. (dissolved fraction)

Temp.:

20 °C

Remarks on result:

other: Solubility of Dimethoxyposphoryloctadecanoic acid (Mono-PFA)

Conclusions:

The water solubility of the test item component Dimethyl-n-propylphosphonate at 20°C was 206 g/L. The pH of the aqueous samples was between 1.2 and 1.4.
The water solubility of the test item component Dimethoxyposphoryloctadecanoic acid (Mono-PFA) at 20°C was 0.0235 g/L. The pH of the aqueous samples was between 3.3 and 3.7.

Executive summary:

The objective of this study was to determine water solubility for Fatty acids, C18-unsatd., phosphates following EC Guideline A.6, OECD Guideline105, EPA OPPTS 830.7840 and GLP principles. Since the test item is an UVCB with expected surface active properties (based on the composition), the water solubility was measured by the shake flask method at two different loading rates based on the two main components that covered the wide water solubility range, i.e. Dimethyl-n-propylphosphonate with an expected high solubility and Dimethoxyphosphoryloctadeconaoic acid (mono-PFA) with a low solubility. The water solubility of the test item component Dimethyl-n-propylphosphonateat 20°C was 206 g/L. The water solubility of the test item component Dimethoxyposphoryloctadecanoic acid (Mono-PFA)at 20°C was 0.0235 g/L.

 

 

Description of key information

The flask method was applied for the determination of the water solubility of Fatty acids, C18-unsatd., phosphates following EC Guideline A.6, OECD Guideline 105, EPA OPPTS 830.7840. and GLP principles. A method was developed to determine the solubility of the major alkylphosphonate and the other phosphorylated and non-phosphorylated fatty acids. These components are the most soluble and interesting for the toxicity studies. The overall range water solubility values were from 0.0235 g/L to 206 g/L.

Therefore, the value of 0.0235 g/L has been used as a key value for the chemical safety assessment.

Key value for chemical safety assessment

Water solubility:

0.024 g/L

at the temperature of:

20 °C