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Diss Factsheets
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EC number: 294-955-2 | CAS number: 91771-62-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cyperus scariosus, Cyperaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Human Repeated Insult Patch (HRIPT)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 13/09/2006-05/12/2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- The LLNA study conducted resulted in non-conclusive outcome.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Marzulli-Mailbach method was used to carry out Human Repeated Insult Patch test to study sensitization potential of a product in human volunteers. The test item was applied in maximized conditions (occlusion or semi-occlusion) during 3 weeks (Induction phase). After two-week rest phase, the products are reapplied on the same sites (Challenge phase). If the product is allergenic, it induces a cutaneous reaction during the challenge phase.
- GLP compliance:
- yes
- Remarks:
- Standards of Good Clinical Practice Guidelines according to guidelines of ICH
- Type of study:
- other: Marzulli-Maibach method
Test material
- Reference substance name:
- Cyperus scariosus, ext.
- EC Number:
- 294-955-2
- EC Name:
- Cyperus scariosus, ext.
- Cas Number:
- 91771-62-9
- IUPAC Name:
- Cyperus scariosus, ext.
- Test material form:
- liquid
Constituent 1
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: Day 36
- Hours after challenge:
- 0
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: Day 37
- Hours after challenge:
- 24
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: Day 38
- Hours after challenge:
- 48
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: Day 39
- Hours after challenge:
- 72
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- other: Day 40
- Hours after challenge:
- 96
- Group:
- test chemical
- No. with + reactions:
- 0
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the Human Repeated Insult Patch (HRIPT) study no signs of sensitizing potential of test item, Cyperus scariosus, ext was detected.
- Executive summary:
Marzulli-Mailbach method was used to carry out Human Repeated Insult Patch test to study sensitization potential of test item in 100 human volunteers.The application of 15% of the Cyperus scariosus, ext. item did not cause signs of sensitization.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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