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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 924-043-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Additional information on environmental fate and behaviour
Administrative data
- Endpoint:
- additional information on environmental fate and behaviour
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study following sound scientific principles. This is a non-standard, proprietary study specifically designed and conducted in order to provide supporting evidence to the testing program. Acceptable with restrictions.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Ecotoxicity screening studies were conducted in which a biomimetic extraction technique using solid-phase microextraction (SPME) in conjunction with gas chromatography (GC) was employed to assess the level of water soluble hydrocarbons and hence the potential toxicity of the water accommodated fractions (WAFs) of the test samples. In addition, the toxicity of WAFs was also monitored using an in-vitro MicrotoxTM assay, a biosensor-based measurement system.
- GLP compliance:
- no
- Type of study / information:
- Leaching of the thickener from base oils for a range of greases
Test material
- Reference substance name:
- Tetraurea 2
- IUPAC Name:
- Tetraurea 2
- Test material form:
- other: Grease: thickener in a base oil
- Details on test material:
- Tetraurea 2 base grease in normal base oil
Constituent 1
Results and discussion
Any other information on results incl. tables
Results and Conclusions
The SPME and Microtox results for the WAFs of the grease samples at 1000 mg/L loading rate are as follows:
Grease sample | SPME-GC | Microtox reading | |
(Total peak area) | (5 min) | (15 min) | |
Tetraurea thickener 2 base grease | 503,192 | >100 | >100 |
Both sets of screening data confirm that there is no apparent toxicity associated with any of the samples at the 1000 mg/L loading rate. The SPME-GC data summarised above, supported by the chromatograms, confirm that the total peak area counts are all extremely low and equivalent to background readings associated with a control sample (i.e. a WAF without any test sample added).
The screening ecotoxicity data (using SPME-GC and the in-vitro Microtox assay), confirm a lack of toxicity of the greases.
Applicant's summary and conclusion
- Conclusions:
- There is negligible leaching of the thickeners from base oils in the samples tested. The SPME-GC data confirm that the total peak area counts are all extremely low and equivalent to background readings associated with a control sample.
- Executive summary:
It was proposed that leaching studies be undertaken on thickeners in base oils to provide additional support to the grease thickener testing strategy. Information generated during the screening studies will be of relevance and value to the risk assessment of a wide range of grease thickeners and to assess the potential bioavailability of grease and other lubricant components.
The approach for the PU thickeners was to use a solid-phase microextraction (SPME) method combined with gas chromatography (GC) to assess the bioaccumulation potential of the water accommodated fractions (WAFs) of PU based grease. This approach was also used to assess the availability of the organic complexes of the metal based grease thickeners (e.g. Lithium based complexes) and complemented with metal ion analysis.
Ecotoxicity screening studies were conducted in order to determine whether there was any toxicity associated with the grease samples. The toxicity of WAFs was monitored using an in-vitro Microtox assay, a biosensor-based measurement system. The screening ecotoxicity data (using SPME-GC and the in-vitro Microtox assay), confirm a lack of toxicity of the greases.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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