Registration Dossier
Registration Dossier
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EC number: 201-383-9 | CAS number: 81-88-9
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS: Ammonium, (9-(o-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride
- Author:
- unknown
- Year:
- 1 961
- Bibliographic source:
- RTECS number BP3675000 citing TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-1959- Volume(issue)/page/year:3,696,1961
- Reference Type:
- review article or handbook
- Title:
- RTECS: Ammonium,(9-(o-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene)diethyl-, chloride
- Author:
- unknown
- Year:
- 1 963
- Bibliographic source:
- RTECS no BP3675000 citing Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases.(V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36,1957-1992. For publisher information, see MTPEEI.Volume(issue)/page/year: 7(2),34,1963
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no information on the method
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- EC Number:
- 201-383-9
- EC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- Cas Number:
- 81-88-9
- Molecular formula:
- C28H31N2O3.Cl
- IUPAC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- not specified
Doses / concentrations
- Dose / conc.:
- 110 other: mg/kg/13W-I
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi
- Histopathological findings: neoplastic:
- not specified
Effect levels
- Remarks on result:
- not measured/tested
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Basic violet 10 was administered by inhalation route to rats for 13 weeks.
Some effects were observed: structural or functional change in trachea or bronchi, weight loss or decreased weight gain, death.
The Lowest published toxic dose (TDLo) was 110 mg/kg/13W-I.
No further information was provided.
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