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EC number: 212-104-5 | CAS number: 762-72-1
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 Feb to 29 Mar 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Department of Health of the Government of the United Kingdom, Medicines and Heathcare products Regulatory Agency (MHRA)
- Type of method:
- method to determine freezing temperature
- Melting / freezing pt.:
- < -20 °C
Reference
Results
Cooling data for Determinations 1 and 2 are shown in the following tables.
Table 1: Determination 1
Time (s) |
Temperature (°C) |
Time (s) |
Temperature (°C) |
Time (s) |
Temperature (°C) |
0 |
20.5 |
480 |
-2.0 |
960 |
-14.5 |
30 |
19.0 |
510 |
-3.0 |
990 |
-15.0 |
60 |
17.0 |
540 |
-4.0 |
1020 |
-15.5 |
90 |
15.0 |
570 |
-5.0 |
1050 |
-16.5 |
120 |
13.5 |
600 |
-6.0 |
1080 |
-17.0 |
150 |
12.0 |
630 |
-7.0 |
1110 |
-17.0 |
180 |
10.5 |
660 |
-7.5 |
1140 |
-17.5 |
210 |
9.0 |
690 |
-8.5 |
1170 |
-18.0 |
240 |
7.5 |
720 |
-9.5 |
1200 |
-18.5 |
270 |
6.0 |
750 |
-10.0 |
1230 |
-19.0 |
300 |
4.5 |
780 |
-11.0 |
1260 |
-19.0 |
330 |
3.5 |
810 |
-11.5 |
1290 |
-19.5 |
360 |
2.5 |
840 |
-12.0 |
1320 |
-20.0 |
390 |
1.5 |
870 |
-13.0 |
1350 |
-20.0 |
420 |
0.0 |
900 |
-13.5 |
1380 |
-20.5 |
450 |
-1.0 |
930 |
-14.0 |
1410 |
-21.0 |
Observations: The test item did not change during cooling.
Result: Freezing temperature: <-20 °C (<253 K)
Table 2: Determination 2
Time (s) |
Temperature (°C) |
Time (s) |
Temperature (°C) |
Time (s) |
Temperature (°C) |
0 |
22.0 |
510 |
-2.5 |
1020 |
-15.5 |
30 |
21.0 |
540 |
-3.5 |
1050 |
-16.0 |
60 |
19.0 |
570 |
-4.5 |
1080 |
-16.0 |
90 |
17.5 |
600 |
-5.5 |
1110 |
-16.5 |
120 |
15.5 |
630 |
-6.5 |
1140 |
-17.0 |
150 |
14.0 |
660 |
-7.0 |
1170 |
-17.5 |
180 |
12.0 |
690 |
-8.0 |
1200 |
-18.0 |
210 |
10.5 |
720 |
-9.0 |
1230 |
-18.5 |
240 |
9.0 |
750 |
-9.5 |
1260 |
-18.5 |
270 |
7.5 |
780 |
-10.5 |
1290 |
-19.0 |
300 |
6.5 |
810 |
-11.0 |
1320 |
-19.5 |
330 |
5.0 |
840 |
-12.0 |
1350 |
-20.0 |
360 |
3.5 |
870 |
-12.5 |
1380 |
-20.0 |
390 |
2.0 |
900 |
-13.0 |
1410 |
-20.5 |
420 |
1.0 |
930 |
-13.5 |
1440 |
-20.5 |
450 |
0.0 |
960 |
-14.0 |
1470 |
-21.0 |
480 |
-1.5 |
990 |
-15.0 |
|
|
Observations: The test item did not change during cooling.
Result: Freezing temperature: <-20 °C (<253 K)
Overall Result: Freezing temperature: <-20 °C (<253 K)
Conclusion
The freezing point of the test item has been determined to be less than -20 °C (<253 K).
Description of key information
Freezing temperature: <-20 °C, at 1013 hPa (OECD 102, crystallizing point method)
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -20 °C
Additional information
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