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EC number: 258-380-0 | CAS number: 53126-67-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dibutyl hydrogen phosphate
- EC Number:
- 203-509-8
- EC Name:
- Dibutyl hydrogen phosphate
- Cas Number:
- 107-66-4
- Molecular formula:
- C8H19O4P
- IUPAC Name:
- dibutyl hydrogen phosphate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Nippon Charles River (Co., Ltd.)
- Age at study initiation: 5 weeks
- Weight at study initiation: males 149 (137-153) g, females 122 (118-129) g
- Fasting period before study: from 5 pm in the evening prior to dosing (dosing time: 10.49-11.00 am)
- Housing: During the acclimation period and the pre-dosing observation period, the animals were housed, sex-segregated, in stainless steel mesh cages (276 mm wide × 426 mm deep × 200 mm high), 2-3 animals per cage, in a barrier system animal house
- Diet: ad libitum, Labo MR Stock solid feed, manufactured by Nihon Nosan Kogyo K.K., batch number 92.1 0.67
- Water: tap water
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 55 ± 10
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 w/v %
- Amount of vehicle: 10 mL/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: On the dosing day, general observation of symptoms and confirmation of survival was undertaken once within 1 hour of dosing, once approximately 3 hours after dosing and once approximately 6 hours after dosing. This was taken as day 0. From the following day (day 1) onwards, observation was undertaken at least once a day. Bodyweight was measured immediately before dosing (day 0), and on days 1, 3, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- not necessary
Results and discussion
- Preliminary study:
- In preliminary experiments undertaken to set the dose, no male or female fatalities were observed even on administration of 2000 mg/kg bw.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- other: After administration of 2000 mg/kg bw there were no male or female fatalities. On general observation of the symptoms after dosing, decreased locomotor activity, deepening respiration, eyelid ptosis, salivation, urine-stained abdomens, excretion of red ur
- Gross pathology:
- No abnormalities were observed visually in any of the males or females on necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 value of the test substance is > 2000 mg/kg bw.
- Executive summary:
A study of the acute oral toxicity of the test item in rats was undertaken. No fatalities were observed after administration of 2000 mg/kg bw (chosen on the basis of the results of preliminary test). The symptoms of toxicity observed in males and females after dosing were as follows: there were symptoms of systemic suppression such as decreased locomotor activity, deepening respiration and eyelid ptosis. Abdomina were urine-stained and on the day after dosing inhibition of body weight increase or body weight decrease was observed. Some animals exhibited transient salivation and the excretion of red urine. There was recovery such that by 4 days after dosing none of these changes were observed anymore. Necropsy revealed no visible abnormalities of the organs. From these results it was concluded that the minimum lethal dose and thus also the LD50 is higher than 2000 mg/kg bw.
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