4-[(6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 2

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

other:

Reference 3

Endpoint:

self-heating substances / mixtures

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Reference 4

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003-06-23 to 2003-07-10

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

Remarks:

The testing facility indicated that the protocol was followed without deviation.

GLP compliance:

yes (incl. QA statement)

Remarks:

from the Swiss GLP Monitoring Authorities

Specific details on test material used for the study:

- Batch n°: 00403487
- Analytical purity: > 98%
- Expiration date: 31 December 2003
- Storage condition: at room temperature

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

T002615 could not be ignited with a flame during the preliminary test (contact time of about 2 minutes). In contact with the ignition source, T002615 melted and a dark brown to beige shiny melt remained. Therefore, no main test was performed.

Interpretation of results:

GHS criteria not met

Conclusions:

In conclusion, T002615 is not ''highly flammable'' according to the criteria described in the guidance.

Description of key information

The flammability potential of T002615 was determined in a GLP study according to the EU Method A.10 (Klimisch 1, Tognucci, 2003).

According to the results of the preliminary test, performance of the burning rate test was not required. T002615 is considered as not readily combustible (i.e. not flammable). Further, T002615 is not considered a pyrophoric substance, a substance which emits flammable gases after contact with water or a self-heating substance (no tests performed, waiving based on theoretical assessment and experience in day-to-day handling and use).

Key value for chemical safety assessment

Flammability:

not classified

Justification for classification or non-classification

The substance does not need to be classified as flammable, self-heating, pyrophoric or as a substance which emits flammable gases in contact with water.