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Diss Factsheets
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EC number: 222-426-8 | CAS number: 3468-11-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- 1-imino-1H-isoindol-3-amine
- Type of composition:
- legal entity composition of the substance
- State / form:
- solid: particulate/powder
- Reference substance:
- 1-imino-1H-isoindol-3-amine
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence assessment
The substance has been evaluated in a ready biodegradation study according to OECD 301B (CO2 evolution). The degradation started quickly but reached a plateau after 11 days. Up to 55 % biodegradation within 28 days was observed. However, since the pass levels were not reached within the 10-day window, the substance is regarded as 'not readily biodegradable'.
Also abiotic degradation was assessed in an hydrolysis experiment according to OECD 111. At pH 4, pH 7 and pH 9 hydrolysis was observed. The half-life at pH 4 is determined to be 0.9 days at 20°C, at pH 7 the half-life at 20°C is 3.9 days and at pH 9 a half-life of 4.4 days was observed at 20°C.
Based on the available information on biodegradation and hydrolysis it can be assumed that the substance is not P.
Bioaccumulation assessment
For this substance only information on the partition coefficient is available. The partition coefficient was assessed according to OECD 107, shake flask method. The log Pow value is 0.62, which is very low. Based on this information, the log Kow is well below the screening cut-off log Kow = 4.5.
Additionally, a QSAR model (BCFBAF v3.01, available in EpiSuite) has been ran to check the bio-accumulation potential. The calculated BCF using the measured log Kow value of 0.62 was 3.162 L/kg. This value is well below 2000 L/kg, the cut-off value for bio-accumulation.`
We hence conclude that the substance is most likely not B.
Toxicity assessment
The test substance was found to be mutagenic in the in vitro mammalian cell gene mutation assay (Thymidine kinase locus) in mouse lymphoma L5178Y cells. Further testing is required to assess the genetic toxicity potential of this substance and to conclude on its CMR properties.
Based on the available ecotoxicological information and awaiting further testing to assess the genotox properties, the substance should not be considered T.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.