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EC number: 240-458-0 | CAS number: 16409-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- not GLP
- Justification for type of information:
- This information is used for read-across to Neryl acetate multi.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- no details on test material (purity not indicated), no details on environmental conditions.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Neryl acetate
- EC Number:
- 205-459-2
- EC Name:
- Neryl acetate
- Cas Number:
- 141-12-8
- Molecular formula:
- C12H20O2
- IUPAC Name:
- (2Z)-3,7-dimethylocta-2,6-dien-1-yl acetate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not mentioned
- Age at study initiation: Not specified
- Weight at study initiation: 2 - 3 kg
- Housing: housed individually in metabolism cages
- Diet: Free acces to rabbit pellets
- Water: Free access to tap water.
- Acclimation period: At least 14 days.
During acclimation period: hematology consisting of a red and white cell count, differential, grams hemoglobin, per cent hematocrit and a urinalysis was performed on each animal.
ENVIRONMENTAL CONDITIONS
Not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Clipped and abraded back skin
- Coverage: Rubber sleeve or dam
REMOVAL OF TEST SUBSTANCE
- Via wiping
- Time after start of exposure: 24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 2.0 mL/kg bw
3.9 mL/kg bw
6.0 mL/kg bw - No. of animals per sex per dose:
- 4
- Control animals:
- not required
- Details on study design:
- Study Design:
On the day before application the rabbits were clipped free of fur on the back using small animal clippers. Backs were further prepared by making epidermal abrasions every two/three centimers that did not penetrate the stratunum corneum. Test item was applied to clipped intact and abraded skin and thereafter covered with a rubbersleeve or dam. Animals were placed in a multiple animal holder for 24 hours. During this period animals were allowed its daily ration of rabbit pellets and water. After 24 hours, the rubbersleeve or dam was removed and treated skin was wiped thoroughly.
Observations:
Animals were observed for 14 days after the removal of the dressings and test substance.
Effects to the skin were recorded immediatly after removal of the rubbersleeve.
During observation period food consumption and general behaviour were observed
- Other examinations performed: After the 14 day observation period hematology and urinalysis was performed on all animals as was done during the acclimation period.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 466 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred
- Clinical signs:
- other: No skin irritation or other clinical signs were observed
- Gross pathology:
- No data
- Other findings:
- Animals behaved normal during observation period.
No significant changes were seen in the intitial and final hematogram.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acutely harmful.
- Remarks:
- according to EU CLP (EC No. 1272/2008 and its amendments).
- Conclusions:
- The acute dermal LD50 is >5466 mg/kg bw in rabbits.
- Executive summary:
The dermal acute toxicity of Neryl Acetate (‘mono’) was investigated in a study comparable to OECD TG 402 (non-GLP). In this study, three groups of 4 rabbits were administered dermal doses of 2, 3.9, or 6.0 mL (1822, 3553, and 5466 mg/kg bw based on a relative density of 0.911) for 24 hours on intact and abraded skin, followed by a 14-day observation period. Treated skin was covered with a rubber sleeve or dam (occlusive exposure). Examination of treated skin after 24 hours, showed no signs of erythema or oedema, and remained normal during the 14-day observation period. No test item-related effects on feeding, body weight or behaviour were recorded. Haematology and urinalysis revealed no significant changes. No mortalities occurred. Based on these findings, the acute dermal LD50 of Neryl Acetate (‘mono’) was determined to >5466 mg/kg bw.
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