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EC number: 213-485-0 | CAS number: 957-68-6
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 11, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD104) with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculated by extrapolation from higher temperatures.
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculated by extrapolation from higher temperatures.
- Temp.:
- 50 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure at 20 °C was determined to 2.1 x 10E-5 Pa; at 25 °C to 3.1 x 10E-5 Pa.
- Executive summary:
The vapour pressure of the test item 7-Aminocephalosporanic acid was calculated by extrapolation of the measured vapour pressure curve by the effusion method using a vapour pressure balance, according to Regulation EC 440/2008 Method A.4. Vapour Pressure.
Temperature / °C Vapour pressure / Pa
20 2.1 ×10-5
25 3.1 ×10-5
50 1.6 ×10-4
Reference
The vapour pressure was measured in the temperature range of 48 to 119 °C. The measured vapour pressure values together with the measured temperatures are listed inTable 1.
Table1: Results of the Effusion method
No. |
Temperature / °C |
Vapour pressure / Pa |
1 |
48 |
1.32 ×10-4 |
2 |
53 |
2.02 ×10-4 |
3 |
59 |
3.13 ×10-4 |
4 |
69 |
4.28 ×10-4 |
5 |
79 |
7.25 ×10-4 |
6 |
88 |
1.40 ×10-3 |
7 |
98 |
2.26 ×10-3 |
8 |
103 |
3.92 ×10-3 |
9 |
114 |
5.00 ×10-3 |
10 |
119 |
8.16 ×10-3 |
11 |
124 |
1.35 ×10-2 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation
log10p = A + (B/T)
can be derived by regression of the data points to
A = 4.7452
B = -2759.92.
The vapour pressure of the test item7-Aminocephalosporanic acid calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation EC 440/2008 Method A.4.Vapour Pressureare shown inTable2:
Table2: Calculated vapour pressure values for 20, 25 and 50 °C
Temperature / °C |
Vapour pressure / Pa |
20 |
2.1 ×10-5 |
25 |
3.1 ×10-5 |
50 |
1.6 ×10-4 |
Description of key information
The vapour pressure at 20 °C was determined to 2.1 x 10E-5 Pa; at 25 °C to 3.1 x 10E-5 Pa.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
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