Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-481-9 | CAS number: 15467-06-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: cf justification
- Principles of method if other than guideline:
- Évaluer le potentiel d'irritation oculaire de l'adipate de dibutyle chez la souris
- GLP compliance:
- not specified
Test material
- Reference substance name:
- butyl (9Z,12R)-12-(acetyloxy)octadec-9-enoate
- Cas Number:
- 140-04-5
- Molecular formula:
- C24H44O4
- IUPAC Name:
- butyl (9Z,12R)-12-(acetyloxy)octadec-9-enoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Nom du produit d'essai (cité dans le rapport d'étude): Adipate de dibutyle
- Formule moléculaire: C14H26O4
- Poids moléculaire: 258,355 g / mol
- Notation de sourires: C (CCCCC (OCCCC) = O) (OCCCC) = O
- InChI: 1S / C14H26O4 / c1-3-5-11-17-13 (15) 9-7-8-10-14 (16) 18-12-6-4-2 / h3-12H2,1-2H3
- Type de substance: organique
- État physique: liquide
Test animals
- Species:
- mouse
- Strain:
- other: sans poil
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: sans poil
- Vehicle:
- other: acetone
- Controls:
- other: non spécifié
- Amount / concentration applied:
- 10% dans l'acétone
- Duration of treatment / exposure:
- tous les jours durant 10 j
- Observation period:
- 10 j
- Number of animals:
- 5
- Details on study design:
- Détails sur la conception de l'étude
- Zone d'exposition: oreille
SYSTÈME DE NOTATION: pas de données
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 10 j
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Pas d'effet observé.
- Other effects:
- non spécifié
Any other information on results incl. tables
aucun
Applicant's summary and conclusion
- Interpretation of results:
- other: non irritant
- Conclusions:
- L'application d'adipate de dibutyle à 10% dans l'acétone n'a produit aucun effet indésirable lorsqu'elle a été appliquée quotidiennement pendant 10 jours aux oreilles des souris sans poils.
Par conséquent, l'adipate de dibutyle peut être considéré comme non irritant pour la peau. - Executive summary:
Une étude d'irritation de la peau a été réalisée pour évaluer le potentiel d'irritation de l'adipate de dibutyle.
De l'adipate de dibutyle à 10% dans de l'acétone a été appliqué quotidiennement pendant 10 jours aux oreilles de 5 souris sans poils et des effets ont été observés.Aucun effet indésirable n'a été observé après 10 jours.
De ce fait, l'adipate de dibutyle peut être considéré comme non irritant pour la peau.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
