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Diss Factsheets
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EC number: 919-553-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: sieving
- Version / remarks:
- As suggested in the integrated testing strategy for granulometry, outlined in Figure R.7.1-6 of the ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7a: Endpoint specific guidance, Version 5.0, December 2016, the granulometry of Stimulhyal was assessed by sieving through a sieve with 100 µm aperture width.
- Principles of method if other than guideline:
A test sieve with a certified aperture width of 100 µm (VWR collection, serial no. 15175141, conform to DIN ISO 3310, NF ISO 3310, ISO 565, ASTM E11, BS 410) with the corresponding collection pan was used in the present study.
The collecting pan was weighed; the test sieve was inserted into the corresponding collecting pan. An exact quantity of test substance, e.g. 10.00 g, was weighed to the setup.
The test substance was sieved by mechanical agitation for 5 minutes. The amount of test substance collected in the collecting pan was determined. The operation was repeated until the weight of the test substance in the collecting pan did not change by more than 5%.- GLP compliance:
- not specified
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- sieving
- Type of particle tested:
- aggregate
- Type of distribution:
- counted distribution
Test material
- Reference substance name:
- 2-ketogluconic acid, calcium salt
- EC Number:
- 919-553-2
- Cas Number:
- 28098-92-2
- Molecular formula:
- C6H10O7.xCa
- IUPAC Name:
- 2-ketogluconic acid, calcium salt
- Test material form:
- solid
Constituent 1
Results and discussion
Particle size
- Key result
- Percentile:
- D95
- Mean:
- < 100 µm
- St. dev.:
- 0.95
Applicant's summary and conclusion
- Conclusions:
- The tested sample of Stimulhyal contains virtually no particles with a particle size of <100 µm. According to the integrated testing strategy for granulometry, as outlined in Figure R.7.1-6 of the above-mentioned guidance document, further testing is therefore not necessary.
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