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EC number: 215-355-9 | CAS number: 1323-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
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Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April, 1988-July, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study by GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenetics Tests: Erythrocyte Micronucleus Assay)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- Castor oil (CAS 8001-79-4), lot #L-5G30-01, was obtained from Cas Chemical, Inc., Bayonne, NJ. Purity analysis indicated that it was consistent with the USP specifications and the reported composition for castor oil: Analysis was conducted by Midwest Research Institute (MRI), in Kansas City, MO, utilizing infrared, UV/Vis and NMR spectroscopy, Karl Fischer water analysis, TLC and HPLC, and a battery of USP standard analyses for castor oil.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals weight-randomized into groups by sex, assigned to cages and cages assigned to dose groups. Mice were caged individually.
Animals obtained from Simonsen Laboratories, Gilroy CA, USA
Animal room temperature: 68-76 degrees F, relative humidiay 42-72%.
Fluorescent light 12 h/day, 10 room air changes/hour.
Age at initiation of study: 6 weeks
Quaranteed 15 days prior to study.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- NIH 07, available ad libitum
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS:
DIET PREPARATION
- Rate of preparation of diet (frequency): Prepared every 21 days. Feed within animal cages was changed every 3 days.
- Mixing appropriate amounts with (Type of food): NIH07, ad lib
- Storage temperature of food: at 5degrees C, in the dark
VEHICLE
- Justification for use and choice of vehicle (if other than water): NIH07, ad lib - Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- ad libitum
- Post exposure period:
- not applicable; test is performed on peripheral blood from a subchronic study.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.62 other: % in diet
- Remarks:
- Doses / Concentrations:
0, 0.62%, 1.25%, 2.5%, 5.0% and 10%
Basis:
nominal conc.
- Dose / conc.:
- 1.25 other: % in diet
- Dose / conc.:
- 2.5 other: % in diet
- Dose / conc.:
- 5 other: % in diet
- Dose / conc.:
- 10 other: % in diet
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, plain diet
- Positive control(s):
- Urethane (0.2%) was used as a positive control. Three male mice were dosed for 4 weeks with this positive control in the drinking water.
Examinations
- Tissues and cell types examined:
- Peripheral blood, obtained at sacrifice from cardiac puncture.
- Details of tissue and slide preparation:
- Slides were stained with Hoechst 33258/pyronin Y, according to the method of MacGregor, et al., 1983). At least 2000 PCE and 10,000 NCE from each animal were scored for micronuclei.
- Statistics:
- Values are Mean +/- Standard Error of the Mean. Significant differences were assessed using Shirley's test (Shirley, 1977), at p <0.05.
Results and discussion
Test results
- Key result
- Sex:
- male/female
- Genotoxicity:
- negative
- Remarks:
- no increase in micronucleated erythrocytes
- Toxicity:
- no effects
- Remarks:
- no adverse hematologic effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- No significant elevation in the frequency of micronucleated erythrocytes was observed in either male or female mice administered castor oil in dosed feed.
Applicant's summary and conclusion
- Conclusions:
- Castor oil, when administered in the feed to B6C3F1 mice for 13 weeks, did not result in an increase in micronucleated erythrocytes. The substance is not a genotoxicant, under the conditions of the study.
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