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EC number: 205-785-5 | CAS number: 151-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 March 2018 to 19 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Version / remarks:
- 2009
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- The test substance is listed as Butyl Ricinoleate (CAS 151-13-3). The test substance was obtained from the Sponsor, Vertellus Holdings LLC and stored at ambient conditions.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- The test was carried out using the unicellular green alga, Pseudokirchneriella subcapitata. Liquid cultures of Pseudokirchneriella subcapitata were obtained from the Culture Collection of Algae, University of Texas at Austin (UTEX). Master cultures were maintained in the laboratory by the periodic replenishment of culture medium. The master cultures were maintained in the laboratory under the same conditions as the definitive test.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 22.7 °C to 24.1 °C
- pH:
- 7.4 to 8.1
- Nominal and measured concentrations:
- Following a preliminary range-finding test, a definitive limit test was conducted with nominal concentrations of 0 (control), 0.30, 0.95, 3.1, 9.8, 31, and 100 mg TP/L using a water accommodated fraction (WAF).
- Reference substance (positive control):
- no
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 67.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a Water Accomodated Fraction (WAF).
- Duration:
- 72 h
- Dose descriptor:
- EC20
- Effect conc.:
- 21.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a Water Accommodated Fraction (WAF).
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 11.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a Water Accommodated Fraction (WAF).
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a Water Accommodated Fraction (WAF).
- Validity criteria fulfilled:
- yes
- Remarks:
- Cell conc. of control increased by a factor of >16 after 72 h (protocol ≥ factor of 16); mean of coeff. of variation for growth rates control <35% (protocol ≤ 35%); coeffi. of var.of avg. sp. growth rate in replicate control cultures <7% (protocol ≤ 7%).
- Conclusions:
- The test substance caused a reduction of growth in the algal cultures (test units) exposed to a series of nominal test concentrations of the test item prepared with a water accommodated fraction (WAF) for 72 h; therefore, there were toxic or inhibitory effects. The 72-h EC50 (based on growth rate) was 67.8 mg TP/L (95% Confidence Limits 62.2 – 73.3 mg TP/L). The 72-h NOEC (based on growth rate) was 3.1 mg TP/L).
Reference
Description of key information
The key study was a static acute toxicity test on the effects of the substance on the freshwater unicellular green alga,Pseudokirchneriella subcapitata following OECD Guideline 201. The test substance caused a reduction of growth in the algal cultures (test units) exposed to a series of nominal test concentrations of the test item prepared with a water accommodated fraction (WAF) for 72 h; therefore, there were toxic or inhibitory effects. The 72-h EC50, 72-h EC20, 72 -h EC10 and 72-h NOEC (based on growth rate) were reported as 67.8 mg total product (TP)/L, 21.9 mg TP/L, 11.3 mg TP/L and 3.1 mg TP/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 67.8 mg/L
- EC10 or NOEC for freshwater algae:
- 11.3 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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