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Diss Factsheets
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EC number: 236-195-6 | CAS number: 13223-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented report of a guideline study conducted to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- - Name of test material (as cited in study report): MADQUAT MC 75
- Substance type: organic
- Physical state: liquid
- Analytical purity: 75%
- Impurities (identity and concentrations): Water (25%)
- Composition of test material, percentage of components: 100%
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: stable
- Storage condition of test material: at room temperature and away from the light
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
- Sampling method: at 0 and 48 hours
- Sample storage conditions before analysis: no data
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Ultrapure water (ultrafiltration, activated carbon, ion exchange, 0.22 micron filter
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Strain: Clone 5 (Clone A)
- Source: In-house
- Age at study initiation: less than 24 hours
- Feeding during test: no
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): no data
- Type and amount of food: microscopic algae
- Feeding frequency: no data
- Health during acclimation (any mortality observed): no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- Not specified
- Test temperature:
- 19.5-20.5°C
- pH:
- 7.60 to 7.82
- Dissolved oxygen:
- 8.1 to 8.5 mg O2/l
- Nominal and measured concentrations:
- Nominal (mg/l): 0, 100, 135, 182.8, 246, 332.1, 448.4
Measured (initial) (mg/l): 0, 104.3, 145.1, 197.6, 267.4, 362.3, 488.2
Measured (final) (mg/l): 0, 91.8, 127.3, 174.0, 237.9, 322.5, 435.6 - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 ml beakers
- Aeration: non
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ultrapure
- Total organic carbon: not specified
- Particulate matter: not specified
- Metals: Ca and Mg = 2,5 mmol/l
- Pesticides: not specified
- Chlorine: not specified
- Alkalinity: not specified
- Ca/mg ratio: 4
- Conductivity: not specified
- Culture medium different from test medium: no
- Intervals of water quality measurement: not specified
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 24 hours darkness
- Light intensity: not applicable
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): immobilization
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not specified
- Range finding study: yes
- Test concentrations: 0.1 to 100 mg/l
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 104.3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 488.2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 104.3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 488.2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50/24 h: 0.83 mg/l
Any other information on results incl. tables
Concentration |
Immobilisation |
||||
Nominal |
Measured |
||||
Initial (mg/l) |
Final (mg/l) |
Final/initial | 24 hours (%) |
48 hours (%) |
|
448.4 | 488.2 | 435.6 | 89.2 | 20 | 25 |
332.1 | 362.3 | 322.5 | 89.0 | 15 | 20 |
246.0 | 267.4 | 237.9 | 88.9 | 10 | 10 |
182.8 | 197.6 | 174.0 | 88.0 | 5 | 10 |
135.0 | 145.1 | 127.3 | 87.7 | 5 | 5 |
100.0 | 104.3 | 91.8 | 88.0 | 0 | 0 |
0 | - | - | - | 0 | 5 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- MADQUAT MC 48 has a low toxicity to Daphnia magna under the test conditions. After 48 hours, the NOEC was 104.3 mg/l and the EC50 was over 488.2 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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