Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 290-505-4 | CAS number: 90170-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read across to analogue substance: Skin sensitisation in vivo (non-LLNA), Guinea Pigs, Reliable study to GLP standards
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX - Reason / purpose for cross-reference:
- read-across source
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 12
- Total no. in group:
- 20
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 50%. No with. + reactions: 12.0. Total no. in groups: 20.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 3
- Total no. in group:
- 20
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 50%. No with. + reactions: 3.0. Total no. in groups: 20.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- other: Naive Control
- Dose level:
- 50%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: other: Naive Control. Dose level: 50%. No with. + reactions: 2.0. Total no. in groups: 10.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- other: Naive Control
- Dose level:
- 50%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 48.0. Group: other: Naive Control. Dose level: 50%. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 11
- Total no. in group:
- 20
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: test group. Dose level: 50%. No with. + reactions: 11.0. Total no. in groups: 20.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 10
- Total no. in group:
- 20
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 48.0. Group: test group. Dose level: 50%. No with. + reactions: 10.0. Total no. in groups: 20.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- other: Naive Control
- Dose level:
- 50%
- No. with + reactions:
- 6
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: other: Naive Control. Dose level: 50%. No with. + reactions: 6.0. Total no. in groups: 10.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Reading:
- rechallenge
- Hours after challenge:
- 48
- Group:
- other: Naive Control
- Dose level:
- 50%
- No. with + reactions:
- 5
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 48.0. Group: other: Naive Control. Dose level: 50%. No with. + reactions: 5.0. Total no. in groups: 10.0. Clinical observations: No data.
- Remarks:
- This is the result for the Read across Source Substance Solvent Blue 98
- Interpretation of results:
- not sensitising
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Read across to an analogue substance, Solvent blue 98 was used to predict the sensitising potential of Solvent Blue 79B.
The analogue substance Solvent Blue 98 did not induce delayed contact hypersensitivity in guinea pigs. Based on similarity in composition and structure, it is concluded that Solvent Blue 79B is not sensitising. - Executive summary:
A read across approach was used to predict the skin sensitising potential of Solvent Blue 79B ( Reaction mass of Reaction mass of 1,4-bis[(2-ethylhexyl)amino]-9,10-dihydroanthracene-9,10-dione and1-[(2-ethylhexyl)amino]-4-(3-[(2-ethylhexyl)oxy]propylamino)anthraquinone and 1,4 di (3-[(2-ethylhexyl)oxy]propylamino) anthraquinone
In-vivo (non) LLNA data for an analogue subtance Solvent Blue 98 concluded that the substance did not induce delayed contact hypersensitivity in guinea pigs. Based on similarity in composition and structure, it is concluded that Solvent Blue 79B is not sensitising. The analogue substance is compositionally very similar. It is also anthraquinone based, with aliphatic amine substitutions. Where the Solvent Blue 79B contains ethylhexyl amine groups and ethylhexyl)oxy]propylamino groups, the Solvent Blue 98 contains ethylhexyl, methyl and pentyl groups. There is therefore overlap in the compositions and the structures are very similar. Further supporting information on the readacross approach has been provided in section 13 (Read across justification document)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A read across approach was used to predict the skin sensitising potential of Solvent Blue 79B
In-vivo non LLNA data for an analogue substance, with a similar composition, structure and manufacturing process concluded that the substance did not induce sensitisation following dermal exposure.
The analogue substance is NOT classified as a Skin sensistiser and it is concluded that based on the similar structure, Solvent Blue 79B is not a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does not require classification with respect to skin sensitisation. The classification criteria are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.