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EC number: 908-700-6 | CAS number: 64519-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
No studies are available on the biodegradation of Reaction mass of 1-O-α-D-glucopyranosyl-D-mannitol and 6-O-α-D-glucopyranosyl-D-glucitol, i.e. Isomalt in water. However, QSAR predictions for both of the main components, i.e. 1-O-α-D-glucopyranosyl-D-mannitol (1,1-GPM) and 6-O-α-D-glucopyranosyl-D-glucitol (=6-O-α-D-glucopyranosyl-D-sorbitol) (1,6-GPS) as well as data available for the read-across substance Isomaltulose (=6-O-alpha-D-glucopyranosyl-D-fructose) indicate that Isomalt is expected to be rapidly degraded by microorganisms in the environment. Hydrolysis is not expected to be a main degradation pathway of the substance based on the molecular structure of the components of Isomalt and on the ready biodegradability of the substance. Isomalt has a low potential for bioaccumulation and adsorption to soil and sediment due to low log Kow values in the range of -4.2 to -3.7.
Concerning the environmental fate of the substance, it has additionally been evaluated using the OECD QSAR Toolbox v4.2 by means of the set of profilers relevant for environmental fate endpoints. These results are presented as supporting information. The chemical structure of the substance (smile codes) was used as input parameter for the evaluation. The sugar alcohols in both of the disaccharides are isomers of each other and the prediction is therefore the same for both components of Isomalt. Table 1 summarized the profilers and their output for E-fate relevant endpoints.
Table 1: OECD QSAR Toolbox profiling for E-fate relevant endpoints.
Endpoint |
Relevant Profilers |
OECD QSAR Toolbox Output |
Bioaccumulation: Aquatic |
BCF (upper trophic) |
-0.049 log(L/kg bdwt) |
Bioaccumulation metabolism half-lives |
Very fast |
|
Biodegradation |
Biodegradation primary (Biowin 4) |
hours - days |
Biodegradation probability (Biowin 1) |
Biodegrades Fast |
|
Biodegradation probability (Biowin 2) |
Biodegrades Fast |
|
Biodegradation probability (Biowin 5) |
Biodegrades Fast |
|
Biodegradation probability (Biowin 6) |
Biodegrades Fast |
|
Biodegradation probability (Biowin 7) |
Biodegrades Fast |
|
Biodegradation ultimate (Biowin 3) |
days - weeks |
|
Bioaccumulation/Biodegradation (PBT) |
Example Prioritization Scheme (PBT) |
not B|not P |
The OECD QSAR Toolbox results support the available QSAR and read across data on biodegradation (Biowin profilers) showing that the substance biodegrade fasts. Furthermore, the profilers “BCF (upper trophic)” and “Bioaccumulation metabolism half-lives” verify that the substance is not expected to bioaccumulate in aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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