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EC number: 256-917-3 | CAS number: 51022-74-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- No data are available for iotroxic acid (target substance). Thus, iotroxic acid, disodium salt (source substance) is used to assess the aquatic toxicity of iotroxic acid in a read-across approach.
Data describing the acute aquatic toxicity of iotroxic acid is based on read-across from iotroxic acid, disodium salt. In aqueous solution disodium salt disassociates to iotroxic acid - Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- In accordance with the OECD 301 F, the test compound iotroxic acid, disodium salt is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge.
- Executive summary:
A Manometric Respirometry Test according to OECD 301 F (July 1992) was conducted in order to investigate the ready biodegradability of iotroxic acid, disodium salt (purity 99.5%). The biodegradation of the test item was studied in reconstituted water inoculated with activated sludge from a municipal wastewater treatment plant with a concentration of suspended solids between 9 to 15 mg/L.
The Manometric Respirometry Test determines the ready biodegradability of test items following their oxygen consumption in closed flasks at a constant temperature (±1 °C) in a range of 20 – 24 °C. The consumption of oxygen is determined by measuring the negative pressure in the flasks after absorption of the evolved carbon dioxide in the absorbing agent (e.g. soda lime). A solution or suspension of the test item in a mineral medium, corresponding to 200 mg/L of theoretical oxygen demand (ThOD), is inoculated with activated sludge for 28 days. The amount of oxygen taken up by the microbial population during the biodegradation of the test item (corrected for uptake by blank inoculum, run in parallel) is expressed as a percentage of the ThOD or the chemical oxygen demand (COD). The pass level for ready biodegradability is 60 % of ThOD and must be reached within a 10-d window. The 10-d window begins when the degree of biodegradation reaches 10 %.The test method is suitable for water soluble and non-soluble test items that are non-volatile and not toxic under the test conditions.
The test compound iotroxic acid, disodium salt was not degraded up to day 29 (28 days of incubation).
The reference compound sodium acetate was degraded to 89 % on day 29 (28 days of incubation). 60% degradation was reached between day 2 and 6.
In the toxicity control, the reference compound (sodium acetate) plus the test compound iotroxicacid disodium salt, was degraded to 44 % on day 29 (28 days of incubation), which reflected thedegradation in the individual sets.
In conclusion, the test is valid according the criteria set by the OECD guideline. Iotroxic acid, disodium salt is considered to be not readily biodegradable based on ThOD.
No data are available for iotroxic acid (target substance). Thus, iotroxic acid, disodium salt (source substance) is used to assess the aquatic toxicity of iotroxic acid in a read-across approach.
Data describing the acute aquatic toxicity of iotroxic acid is based on read-across from iotroxic acid, disodium salt. In aqueous solution disodium salt disassociates to iotroxic acid
Reference
Description of key information
No data is available for iotroxic acid (target substance). Thus, iotroxic acid, disodium salt (source substance) is used to assess the biodegradation of iotroxic acid in water in a read-across approach.
In accordance with the OECD 301 F, the test compound iotroxic acid, disodium salt is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
This information is used in a read-across approach in the assessment of the target substance.
No data are available for iotroxic acid (target substance). Thus, iotroxic acid, disodium salt (source substance) is used to assess the aquatic toxicity of iotroxic acid in a read-across approach.
Data describing the acute aquatic toxicity of iotroxic acid is based on read-across from iotroxic acid, disodium salt. In aqueous solution disodium salt disassociates to iotroxic acid
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