Registration Dossier
Registration Dossier
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EC number: 207-987-9 | CAS number: 504-24-5
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-pyridylamine
- EC Number:
- 207-987-9
- EC Name:
- 4-pyridylamine
- Cas Number:
- 504-24-5
- Molecular formula:
- C5H6N2
- IUPAC Name:
- nickel
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- Method: Test solutions were prepared by mixing a stock solution of the test substance, which was prepared by dissolving the substance in test water. - Test water: dechlorinated tap water
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Feeding during test: no
Study design
- Test type:
- static
- Water media type:
- other: dechlorinated tap water
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- ca. 20 °C
- Nominal and measured concentrations:
- 60.0, 30.0, 15.0, 7.50, 3.75, 1.88 mg/L (geometric ratio 2.0) and control
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Lowest concentration causing 100 % immobility (48 h): 60.0 mg/L,
- Highest concentration causing 0 % mortality (48 h): 1.88 mg/L,
(All results were based on the nominal values.)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 (48h) = 14.5 mg/L
- Executive summary:
EC50 (48h) = 14.5 mg/L
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