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EC number: 236-502-3 | CAS number: 13410-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 March 2004 to 15 April 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1993
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO DIS 9408 (Ultimate Aerobic Biodegradability - Method by Determining the Oxygen Demand in a Closed Respirometer)
- Version / remarks:
- 1999
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Municipal activated sludge from laboratory wastewater treatment plants fed with municipal sewage.
- Sludge was pre-aerated for about 24 hours before begin of exposition.
- Concentration of dry substance: 30 mg/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- ca. 100 mg/L
- Based on:
- test mat.
- Initial conc.:
- 2 572 other: mg/g
- Based on:
- ThOD
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Inorganic medium
- Test temperature: 22 ± 1°C
- pH: 7.6
- Suspended solids concentration: 30 mg/L
- The test was performed with 7 replicates of the test material (ca. 100 mg/L).
SAMPLING
- Sampling frequency: daily for 28 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: in duplicate containing medium and inoculum only.
- Inhibition control: a single test vessel containing the test material (100.4 mg/L), aniline (100 mg/L) with inoculum and medium.
- Abiotic control: a single test vessel containing the test material (100.8 mg/L), HgCl2 (250 µL) and medium.
- Reference control: a single test vessel containing aniline (100 mg/L) with inoculum and medium. - Reference substance:
- aniline
- Test performance:
- VALIDITY CRITERIA
- Deviation of the degradation degree of the test material in the plateau phase < 20%: yes
- Degradation degree of the reference substance > 60% after 14 days: yes
- Degradation degree in the inhibition control > 25% after 14 days: yes
- Oxygen demand in the blank control < 60 mg/L at the end of the test: yes
- pH values in the test assays ranged from pH 6 to 8,5 at the end of the test: yes
- The test is valid: yes - Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 10
- Sampling time:
- 28 d
- Details on results:
- - Percentage biodegradation values for all conditions can be seen in Table 1.
- Results with reference substance:
- - After 14 days the reference material had 76 % biodegradation.
- After 28 days the reference material had 80 % biodegradation.
- This means the reference material was acceptable according to the validity criteria of the test. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Under the conditions of this study the test material was not readily biodegradable.
- Executive summary:
The ready biodegradability of the test material was investigated in accordance with the standardised guidelines OECD 301F, EU Method C.4-D and ISO 9408, under GLP conditions.
Municipal activated sludge from laboratory wastewater treatment plants fed with municipal sewage was used for the test at a concentration of dry substance 30 mg/L.
After 28 days the test material exhibited less than 10% biodegradation. The positive control exhibited 76% biodegradation after 14 days and 80% biodegradation after 28 days. All of the validity criteria of the test were met.
Under the conditions of this study the test material was not readily biodegradable.
Reference
Table 1: Biodegradation in relation to the ThOD [%]
Days |
Percentage Biodegradation in Relation to the ThOD (%) |
|||||||||
RS |
IH |
PC |
TM1 |
TM2 |
TM3 |
TM4 |
TM5 |
TM6 |
TM7 |
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
-2 |
-1 |
0 |
0 |
0 |
0 |
1 |
-1 |
0 |
0 |
2 |
-2 |
-1 |
0 |
0 |
1 |
0 |
1 |
-1 |
0 |
1 |
3 |
-1 |
0 |
0 |
0 |
0 |
0 |
1 |
-1 |
0 |
0 |
4 |
19 |
1 |
0 |
0 |
0 |
0 |
0 |
-2 |
0 |
0 |
5 |
56 |
23 |
0 |
-1 |
0 |
-1 |
0 |
-2 |
-1 |
-1 |
6 |
59 |
29 |
0 |
-1 |
-1 |
-1 |
0 |
-2 |
-1 |
-1 |
7 |
64 |
33 |
0 |
-1 |
-1 |
-1 |
0 |
-2 |
-1 |
-1 |
8 |
65 |
34 |
0 |
-1 |
0 |
-1 |
0 |
-2 |
-1 |
-1 |
9 |
67 |
35 |
0 |
-1 |
0 |
-1 |
0 |
-2 |
-1 |
-1 |
10 |
73 |
35 |
0 |
0 |
0 |
-1 |
0 |
-2 |
-1 |
-1 |
11 |
75 |
36 |
0 |
0 |
0 |
-1 |
0 |
-2 |
-1 |
-1 |
12 |
76 |
36 |
0 |
-1 |
0 |
-1 |
0 |
-2 |
-2 |
-1 |
13 |
76 |
36 |
0 |
-1 |
-1 |
-2 |
0 |
-2 |
-2 |
-1 |
14 |
76 |
36 |
0 |
-1 |
0 |
-2 |
0 |
-2 |
-2 |
-1 |
15 |
77 |
36 |
0 |
0 |
0 |
-1 |
0 |
-2 |
-2 |
-1 |
16 |
76 |
36 |
1 |
-1 |
-1 |
-2 |
-1 |
-3 |
-2 |
-2 |
17 |
77 |
36 |
1 |
-1 |
-1 |
-2 |
-1 |
-3 |
-2 |
-2 |
18 |
77 |
37 |
1 |
-1 |
-1 |
-2 |
-1 |
-3 |
-2 |
-2 |
19 |
78 |
37 |
1 |
-1 |
-1 |
-2 |
-1 |
-2 |
-2 |
-1 |
20 |
79 |
37 |
1 |
0 |
-1 |
-2 |
0 |
-2 |
-2 |
-1 |
21 |
78 |
37 |
2 |
-1 |
-2 |
-2 |
-1 |
-3 |
-2 |
-2 |
22 |
78 |
37 |
2 |
-1 |
-2 |
-2 |
-1 |
-3 |
-2 |
-2 |
23 |
79 |
37 |
2 |
-1 |
-2 |
-2 |
-1 |
-3 |
-2 |
-2 |
24 |
79 |
38 |
2 |
0 |
-2 |
-2 |
-1 |
-3 |
-2 |
-2 |
25 |
79 |
38 |
2 |
0 |
-2 |
-2 |
-1 |
-2 |
-2 |
-2 |
26 |
80 |
38 |
2 |
0 |
-2 |
-2 |
-1 |
-2 |
-2 |
-2 |
27 |
79 |
38 |
2 |
-1 |
-3 |
-2 |
-1 |
-3 |
-2 |
-2 |
28 |
80 |
38 |
2 |
-1 |
-3 |
-2 |
-1 |
-3 |
-2 |
-2 |
RS = reference substance, IH = inhibition control, PC = abiotic control, TM = test material
Description of key information
Under the conditions of this study the test material was not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
The potential biodegradation of the test material was investigated in accordance with the standardised guidelines OECD 301F, EU Method C.4-D and ISO 9408, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Municipal activated sludge from laboratory wastewater treatment plants fed with municipal sewage was used for the test at a concentration of dry substance 30 mg/L.
After 28 days the test material exhibited less than 10 % biodegradation. The positive control exhibited 76 % biodegradation after 14 days and 80 % biodegradation after 28 days. All of the validity criteria of the test were met.
Under the conditions of this study the test material was not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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