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EC number: 825-258-9 | CAS number: 1226892-46-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Available information indicates that all AAI subsatnces are corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
As explained in the category justification, For cross-reading in general use is made with data of same or lower EA-length where available, and that of Tall oil + DETA representing the worst case. This dossier is for the substance "Fatty acids C16-18 and C18-unsatd., reaction products with tetraethylenepentamine”. As for the substance itself no toxicological information is available, cross-reading has been applied to TO + DETA.
Tall oil + DETA
was evaluated in an in vivo dermal irritation/corrosion study in
rabbits
The test item was first applied for periods of 3 minutes, 1
hour and 4 hours to a single male New Zealand White rabbit. Since the
test item was irritant but not corrosive on this first animal, it was
then applied for 4 hours to only one other animal. As the test item
showed corrosive properties on this second animal, the study was
considered complete and the test item was not evaluated on a third
animal. The study concluded that Tall oil + DETA is corrosive to rabbit
skin after 4 hours exposure.
Also other in vivo irritation/corrosion studies indicate corrosion to skin following 4 hour application. The table below provides an overview of all available for the group of AAI:
TO + DETA in vivo: Corrosive: Cat.1C
TO + TEPA in vivo: Corrosive: Cat.1C
C16-18, C18 unsat + TEPA in vivo: Corrosive: Cat.1C
An indication for possible threshold effects for irritation comes from two available sensitisation studies on Tall oil + DETA.
In a Guinea pig maximization study for dermal sensitization, a preliminary irritation study evaluated irritation from epidermal exposures to the substance for 24 hrs under occlusion. The highest non-irritating concentration for epidermal exposures was established at 0.5% in corn oil. Epidermal concentrations of 1% resulted to signs of superficial necrosis.
In a local lymph node assay (LLNA) the substance evoked at 0.5% dissolved in acetone/olive oil (4/1, v/v) some slightly irritant effects following epidermal application of 25µg on the ears of mice. At 0.25% no irritation was observed.
There are no eye irritation studies available on an AAI substance. Corrosion to the eye is expected based on dermal corrosion.
There are no data from inhalation studies. However, exposure by inhalation is not likely considering the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI). Furthermore, as the substance is classified as corrosive, no acute toxicity testing should normally be conducted.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Tall oil + DETA is corrosive to rabbit skin after 4 hours exposure. Consequently, it should be classified Corrosive, Cat. 1C .
Corrosive to eyes is assumed for substances for which dermal corrosion has been established and no additional classification is required.
There is no data from inhalation studies. However, in view of the very low vapour pressure of AAI in general, exposure by inhalation is not likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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