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EC number: 211-941-3 | CAS number: 717-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 5, 2015 to Jun 17, 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch No. 6F11027000
- Expiration date of the lot/batch: 2 years after first opening (17-Nov-2017)
- Purity: 96% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A saturated solution was prepared be adding 117 µl/L test item (eq. to 100 mg/L) to corresponding amount of dilution water and stirring slowly for 23.5 hrs
- Eluate: The lower phase of the resulting solution - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/variety: Berlin/Straus
- Sex: female
- Source: bred in-house at LAUS GmbH. Origin is Umweltbundesamt Berlin
- Food type: unicellular green algae (Demodesmus subspicatus)
- Medium: M4-Medium (husbandry) and ISO-Medium (test)
- Medium renewal: twice/week
SELECTION OF DAPHNIA
- ~20hrs before start of test, adult animals separated from the young
- 0.5 hrs before test start, newborn daphnia (aged between 0- 23hrs) were sieved from medium and immediately placed in 250-mL beaker containing dilution water
- after a settling-in period of 30 min, animals which showed no apparent damage were used for the test - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg (CaCO3)/L
- Test temperature:
- 18.5-20.8 °C
- Dissolved oxygen:
- The lowest concentration of dissolved oxygen at the end of the test was 8.7 mg/L.
- Nominal and measured concentrations:
- 100 mg/L,nominal (0.19 mg/L measured geometric mean)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass flask, total volume 65 mL
- Type: closed
- Aeration: None
- No. of organisms per vessel: 5 daphnia
- No. of vessels per concentration: 4 vessels
- No. of vessels per control: 2 vessels
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: deionised water enriched with certain minerals
- Hardness: 250 mg (CaCO3)/L
OTHER TEST CONDITIONS
- Lighting: Diffuse lighting
- Feeding during test: None
EFFECT PARAMETERS MEASURED: Immobility; observed at 24 and 48 hrs - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.19 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.19 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.19 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.19 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The study was performed as a limit test at the nominal concentration of 100 mg/L. Twenty daphnia were exposed to the test item for 48 hours in a static test system. The concentration showed no significant toxicity (5 % immobilisation, respectively one animal). None of the animals were immobilised in the control.
- Results with reference substance (positive control):
- 24-hr EC50 = 1.2 mg/L. Was within the demanded range of 0.6-1.7 mg/L
- The 24h-EC50 of K2Cr2O7 should lie between 0.6 and 1.7mg/L: The 24h-EC50 of K2Cr2O7 was determined as 1.2 mg/L in a separate GLP study
- Immobilisation in the controls may not exceed 10 %: Immobilisation in the controls was 0%
- The concentration of dissolved oxygen at the end of the test must be at least 3 mg/L: The lowest concentration of dissolved oxygen at the end of the test was 8.7mg/L
- The pH-value in the test solutions should not vary by more than 1.5 units during the test: The highest variation was 0.1 units
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study was performed as a limit test at the nominal concentration of 100 mg/L under static conditions. The 24-hr and 48-hr EC50 were determined to be > 0.19 mg/L. These biological results were based on the geometric mean of the measured concentration.
- Executive summary:
The acute toxicity of 1,3,5-triisopropylbenzen was tested under static conditions in a 48-h toxicity study on the water flea (Daphnia magna) following OECD TG 202. Analytical verification of the 100 mg/L test substance concentration reported a geometric mean measured concentration of 0.19 mg/L. Based on nominal concentrations, the 48-h EC50 was determined to be > 100 mg/L with a 48-h NOEC of 100 mg/L.
Reference
Validation Summary of Study
Description of key information
The acute toxicity of 1,3,5-triisopropylbenzen was tested under static conditions in a 48-h toxicity study on the water flea (Daphnia magna) following OECD TG 202. Analytical verification of the 100 mg/L test substance concentration reported a geometric mean measured concentration of 0.19 mg/L. Based on nominal concentrations, the 48-h EC50 was determined to be > 100 mg/L with a 48-h NOEC of 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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