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EC number: 207-005-9 | CAS number: 421-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 April 2017 - 14 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP compliant
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- bulk density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 September 2016 - 11 January 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP compliant
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- 02 October 2012
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Version / remarks:
- 31 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
- Version / remarks:
- June 2002
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- pycnometer method
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL:
- At room temperature
OTHER SPECIFICS:
- Purity/composition correction factor: No correction factor required.
- Test item hanling: No specific handling conditions required, but for practical reason the test item could be kept on ice to avoid evaporation of the material before and between performance of physico-chemical tests. - Key result
- Type:
- bulk density
- Density:
- 1.23 g/cm³
- Temp.:
- 6 °C
- Conclusions:
- The density of 1,1,1-trifluoroacetone at 6ºC ± 1°C was 1.23 g/cm3.
- Executive summary:
Measurement of the density of 1,1,1 -trifluoroacetone was performed using a volumetric flask according to standardised guidelines (OECD TG 109, EU A.3 and OPPTS 830.7300) under GLP conditions.
The test item is a volatile liquid with a boiling temperature of 20.5°C. It was observed that te density of the test item could not be experimentally determined at 20°C due to significant evaporation (gas bubbles) at about 19°C. The density of the test item was determined at a lower constant temperature of about 6°C.
The density of 1,1,1-trifluoroacetone at 6ºC ± 1°C was 1.23 g/cm3.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Version / remarks:
- Adopted March 23, 2006, corrected 26 September 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspection dates: 7 - 11, 14 and 16 September 2015. Date of the certificate: 03 November 2015.
Test material
- Reference substance name:
- 1,1,1-trifluoroacetone
- EC Number:
- 207-005-9
- EC Name:
- 1,1,1-trifluoroacetone
- Cas Number:
- 421-50-1
- Molecular formula:
- C3H3F3O
- IUPAC Name:
- 1,1,1-trifluoropropan-2-one
- Test material form:
- liquid
- Details on test material:
- - Appearence: clear colourless liquid
- Test item storage: in refrigerator (2-8°C)
For further details, see section "confidential details on test material"
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Appearence: clear colourless liquid
- Test item storage: in refrigerator (2-8°C)
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge freshly obtained from a municipal sewage treatment plant receiving predominantly domestic sewage [Waterschap Aa en Maas', 's-Hertogenbosch, The Netherlands]
- Storage conditions: kept under continuous aeration [synthetic air (CO2< 1 ppm): mixture of oxygen (ca. 20%) and nitrogen (ca. 80%)]
- Preparation of inoculum for exposure: before use, the sludge was allowed to settle (35 minutes) and the liquid was decanted for use as inoculum at the amount of 10 mL/L of mineral medium
- Concentration of sludge: 3.9 g/L - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 62.3 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- inorg. C analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: 1 litre mineral medium contains: 10 mL of solution (A), 1 mL of solutions (B) to (D) and Milli-RO water.
*A) 8.50 g KH2PO4, 21.75 g K2HPO4, 67.20 g Na2HPO4.12H2O and 0.50 g NH4Cl dissolved in Milli-Q water made up to 1 litre, pH 7.4+/-0.2
*B) 22.50 g MgSO4.7H2O dissolved in Milli-Q water and made up to 1 litre
*C) 36.40 g CaCl2.2H2O dissolved in Milli-Q water and made up to 1 litre
*D) 0.25 g FeCl3.6H2O dissolved in Milli-Q water and made up to 1 litre
- Test temperature: 20.0 to 21.7 °C
- pH: 7.5 to 7.9
- Suspended solids concentration: 3.9 g/L
- Continuous darkness: yes with a shaking rate sufficient to keep the vessels well mixed and in suspension
- Other: Since 1,1,1-trifluoroacetone was volatile, aliquots of 5.6 µL were added directly to each vessel by injection through the septum, using a glass Hamilton GC syringe, corresponding with 6.7 mg test item/vessel of 107 mL.
TEST SYSTEM
- Number of culture vessels: Five test vessels for analysis at the end of the test and triplicate test vessels for other time intervals for each treatment.
- Measuring equipment: a Shimadzu TOC-VCPH total organic carbon analyzer combined with a Shimadzu ASI-V autosampler
- Test performed in closed vessels due to significant volatility of test substance: Well sealed glass serum vessels
- Other: Pretreatment: 1 mL 7 M NaOH was injected through the septum of each vessel and the vessels were returned to the orbital shaker for 1 h. Thereafter, the vessels were removed from the shaker and allowed to settle. The supernatant was used for IC analysis.
SAMPLING
- Sampling frequency: Inoculum blank and test item: day 1, 7, 14, 23 and 28 / Procedure control and toxicity control: day 1, 7 and 14 / Abiotic control: day 1 and 28. Each sample was analyzed at least in triplicate.
CONTROL AND BLANK SYSTEM
- Inoculum blank: containing inoculated medium
- Procedure control: containing inoculated medium and reference item.
- Test item: containing inoculated medium and test item.
- Toxicity control: containing inoculated medium, reference item and test item.
- Abiotic control: containing untreated medium, test item and sterilising agent.
STATISTICAL METHODS: None
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (inorg. C analysis)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- The relative biodegradation values calculated from the measurements performed during the test period revealed no significant biodegradation of 1,1,1-trifluoroacetone.
In the toxicity control more than 25% biodegradation occurred within 14 days (37%, based on ThCO2). Curves of biodegradation of 1,1,1-trifluoroacetone and reference item are profided in section "Illustration (picture/graph)".
Therefore, the test item was assumed not to inhibit microbial activity.
BOD5 / COD results
- Results with reference substance:
- With the reference substance (benzoic acid, sodium salt), 77% biodegradation occurred within 14 days.
Any other information on results incl. tables
Degradation in Percentage of the Theoretical Maximum IC Production (ThIC)
Nominal day | Microbial degradation in percentage of the ThIC | Degradation | ||
Reference Item | Test Item | Toxicity Control | Abiotic Control | |
1 | 1 | 0 | 0 | -2 |
7 | 78 | 1 | 37 | n.a. |
14 | 77 | 0 | 37 | n.a. |
23 | n.a. | 2 | n.a. | n.a. |
28 | n.a. | 0 | n.a. | -5 |
n.a.: Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test substance, 1,1,1-trifluoroacetone, was not readily biodegradable under the conditions of the Headspace Test performed.
- Executive summary:
Evaluation of the readily biodegradability of 1,1,1-trifluoroacetone was performed in an aerobic, aqueous inoculated medium (Headspace Test) according to standardised guidelines (OECD TG 310) under GLP conditions.
The test item was added to the mineral medium to give a final organic carbon concentration of 20 mg C/L, corresponding with 62.3 mg test item/L. Since 1,1,1-trifluoroacetone was volatile, aliquots of 5.6 µL were added directly to each vessel by injection through the septum, using a glass Hamilton GC syringe, corresponding with 6.7 mg test item/vessel of 107 mL.
The test consisted of five groups:
1. Test item: vessels each containing 1,1,1-trifluoroacetone (CAS NR : 421-50-1) at 20 mg C/L,
2. Toxicity control: vessels each containing 1,1,1-trifluoroacetone (CAS NR : 421-50-1) at 20 mg C/L and reference item at 20 mg C/L,
3. Positive control: vessels each containing reference item at 20 mg C/L,
4. Blank control: vessels containing untreated mineral medium.
5. Abiotic control: vessels containing 1,1,1-trifluoroacetone (CAS NR : 421-50-1) at 20 mg C/L and mineral medium treated with sterilizing agent.
The CO2 evolution resulting from the aerobic biodegradation of the test item was determined by measuring the inorganic carbon (IC) produced in the test vessels in excess of that produced in blank vessels containing inoculated medium only. Biodegradation was expressed as a percentage of the theoretical maximum IC production, based on the quantity of test item (as C) initially added.
The relative biodegradation values calculated from the measurements performed during the test period revealed no significant biodegradation of 1,1,1-trifluoroacetone (CAS NR : 421-50-1). Since all criteria for acceptability of the test were met, this study was considered to be valid.
Therefore, under the conditions of the Headspace Test, 1,1,1 -trifluoroacetone was not readily biodegradable.
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