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EC number: 202-009-7 | CAS number: 90-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January 2018 to 06 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Commission Regulation (EC) No 440/2008 of 30 May 2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), Method A.6. “Water Solubility”, Official Journal of the European Union L 142 of 31 May
- Deviations:
- yes
- Remarks:
- The temperature was out of the required temperature range in 2 occasions with a maximum of 0.5 °C difference. This difference is not significant, so it has no effect to the Study results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for Testing of Chemicals, Guideline No. 105, "Water Solubility", adopted July 27, 1995
- Deviations:
- yes
- Remarks:
- The temperature was out of the required temperature range in 2 occasions with a maximum of 0.5 °C difference. This difference is not significant, so it has no effect to the Study results.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Specific details on test material used for the study:
- No further details specified in the study report.
- Key result
- Water solubility:
- < 8 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- > 7.06 - < 7.19
- Details on results:
- Calibration
Seven concentration levels were tested: 0.001, 0.002, 0.005, 0.02, 0.05, 0.2 and 0.5 µg/mL. The calibration graph was calculated applying weighted linear regression using 1/concentration as weighting factor.
Results of the Column Elution Method
pH of the samples varied in the range of 7.06-7.19.
Samples were analysed with the above HPLC method. The samples were detectable, but their areas were significantly lower than area of lowest calibration. Control water was measured as well in every case, but peak was not detected in control samples - Conclusions:
- In conclusion, the water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined to be below the quantification limit after 8 days equilibration time, considering to the dilution rate, the water solubility of test item is less than 8 µg/L at 20°C ± 0.5°C using the column elution method.
- Executive summary:
The water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined using the column elution method. It was found to be less than 8 µg/L at 20°C ± 0.5°C after 8 days equilibration time.
Reference
Measured concentration of test item from micro-columns
Time (day) |
Micro-column I (~25 mL/h) |
Micro-column II (~12.5 mL/h) |
||
Measured concentration mg/L |
pH |
Measured concentration mg/L |
pH |
|
1 |
<LOQ |
7.08 |
<LOQ |
7.14 |
<LOQ |
7.11 |
<LOQ |
7.17 |
|
2 |
<LOQ |
7.09 |
<LOQ |
7.08 |
<LOQ |
7.10 |
<LOQ |
7.09 |
|
3 |
<LOQ |
7.12 |
<LOQ |
7.18 |
<LOQ |
7.14 |
<LOQ |
7.19 |
|
4 |
<LOQ |
7.21 |
<LOQ |
7.16 |
<LOQ |
7.18 |
<LOQ |
7.17 |
|
7 |
<LOQ |
7.06 |
<LOQ |
7.06 |
<LOQ |
7.08 |
<LOQ |
7.07 |
|
8 |
<LOQ |
7.11 |
<LOQ |
7.19 |
<LOQ |
7.16 |
<LOQ |
7.17 |
|
Mean |
<LOQ |
- |
<LOQ |
- |
Description of key information
The water solubility is less than 8 µg/L at 20°C ± 0.5°C.
Key value for chemical safety assessment
- Water solubility:
- 8 µg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of 6,6’-di-tert-butyl-2,2’-thiodi-p-cresol was determined using the column elution method. It was found to be less than 8 µg/L at 20°C ± 0.5°C after 8 days equilibration time.
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