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EC number: 271-663-3 | CAS number: 68603-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- Deviations from the Guideline: Temperature range was 19.5 – 21.2 °C instead of 20.0 – 24.0 °C. As degradation of the positive control was in the normal range, this is considered as uncritical con-cerning the outcome of the study
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- 6.3 Test System
6.3.1 Specification
Activated sludge from a biologic sewage treatment plant was used as inoculum. The cho-sen plant treats mostly domestic sewage.
6.3.2 Source and Pre-Treatment of inoculum
6.3.2.1 Source
The sludge was taken from the activation basin of the ESN (Stadtentsorgung Neustadt) sewage treatment plant, Im Altenschemel, NW-Lachen-Speyerdorf.
Date of collection: 12. Jan. 2018, batch no: 20180112.
6.3.2.2 Pre-Treatment
The sludge was filtrated, washed with test medium (2x) and re-suspended in test medium. It was then aerated until use. The dry matter was determined to contain 4900 mg of sus-pended solids/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 32.6 mg/L
- Based on:
- other: calculation
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 76
- Sampling time:
- 28 d
- Details on results:
- The 10-day-window began on day 5, at its end, 46 % degradation were reached (graphical evaluation), missing the pass level of 60 % given in the OECD guideline. If a test on the mixture is performed and it is anticipated that a sequential biodegradation of the individual structures is taking place, then the 10-day. Because the test item is a mixture, the 10-day window has not to be taken into account. Therefore, regardless of the 10-day-window the test item is considered as “readily biodegradable within 28 days”.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- All validity criteria were met. Degradation behaviour of positive control and toxicity control was normal. Abiotic degra-dation reached 3.5 %. Both replicates of the test item showed very good correspondence. Degradation values of more than 100 % were calculated. This is due to the fact that the measurement errors of test flasks and control flasks add up when using the equation proposed in the guidelines. If degradation in the toxicity flask is below 25 % after 14 days, the test item can be considered as toxic towards the inoculum. As degradation in the toxicity flask was 71.1 % after 14 days, the test item can be stated as “not toxic towards the inoculum in a concentration of 32.6 mg/L”. For pure substances ready biodegradability is defined in the guidelines as degradation surpassing 60 % within 10 days after reaching a level of 10 %. The 10-day-window began on day 5, at its end, 46 % degradation were reached, missing the pass level of 60 % given in the OECD guideline. If a test on the mixture is performed and it is anticipated that a sequential biodegradation of the individual structures is taking place, then the 10-day window should not be applied to interpret the results of the test. Because the test item is a mixture, the 10-day window has not to be taken into account. Therefore, regardless of the 10-day-window the test item is considered as “readily biodegradable within 28 days”. No observations were made which might cause doubts concerning the validity of the study outcome. The result of the test can be considered valid.
- Executive summary:
The test substance was tested at a nominal concentration of 20 mg organic carbon/L (corresponding to 32.2 mg test substance/L) in test medium following OECD 301B and EU-Method C.4 -C.
Aniline was chosen as positive control. Activated sludge was used as inoculum (concentration in the test 25.0 mg dry matter/L). The test was left running for 28 d. All validity criteria were met. Degradation of the positive control was 80% after 9 d. The following data were determined for the test substance:
degradation at the end of the test 76%
As degradation surpassed 60% in the course of the test, the test substance is considered as readily biodegradable.
Reference
1 Results and Validity
1.1 Results for the Test ItemDeophos 228
¨ The test itemDeophos 228is considered as “readily biodegradable“.
¨ The degree of biodegradation reached 76 % after 28 days.
¨ The 10-day-window began on day 5, at its end, 46 % degradation were reached (graphical evaluation), missing the pass level of 60 % given in the OECD guideline.
¨
If a
test on the mixture is performed and it is anticipated that a sequential
biodegradation of the individual structures is taking place, then the
10-day
window should not be applied to interpret the results of the test.
Therefore the Test substance is considered as “readily biodegradable within 28 days”.
¨ The abiotic degradation reached 3.5 %.
1.2 Validity
All validity parameters and values are presented in the following table:
Table9.2‑a Validity
Parameter |
Criterion |
Found |
Assessment |
IC content of test item solution in medium |
£5% of TC |
0 % |
valid |
CO2emitted by the controls |
< 70 mg/L |
8.9 mg/L |
valid |
Difference within replicates |
£20% |
0.8 % |
valid |
Degradation of positive control > 60% |
≤14 days |
9 days |
valid |
Degradation in the toxicity flask on day 14 |
> 25% |
71.1 % |
non-toxic |
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
The test substance was tested at a nominal concentration of 20 mg organic carbon/L (corresponding to 32.2 mg test substance/L) in test medium following OECD 301B and EU-Method C.4 -C.
Aniline was chosen as positive control. Activated sludge was used as inoculum (concentration in the test 25.0 mg dry matter/L). The test was left running for 28 d. All validity criteria were met. Degradation of the positive control was 80% after 9 d. The following data were determined for the test substance:
degradation at the end of the
test 76%
As degradation surpassed 60% in the course of the test, the test substance is considered as readily biodegradable.
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