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EC number: 230-990-1 | CAS number: 7396-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- from 2002-03-08 to 2002-04-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 1a: GLP Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 92/69/EEC Method C.3
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-methyldidecylamine
- EC Number:
- 230-990-1
- EC Name:
- N-methyldidecylamine
- Cas Number:
- 7396-58-9
- Molecular formula:
- C21H45N
- IUPAC Name:
- bis(decyl)(methyl)amine
- Details on test material:
- - Active ingredient: Didecylmethylamine, dest
- Purity: not specified
- Water solubility: insoluble
- Stability in water: chemically stable (ca. 0.1% aqueous solution)
- Expiration date of the lot/batch: 2004-02
- Storage condition of test material: room temperature, protected from moisture and light
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not relevant
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Stock solution: directly weighing. For the concentration of 0.625 mg/L a stock solution of 62.5 mg/L was prepared.
Dispersion treatment: the test medium was mixed with a laboratory blender.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: Aquarium am Aegi, Hannover
- Average length at study initiation: 2.76 cm
- Average weight at study initiation: 0.24 g
ACCLIMATION
- Acclimation conditions: 23°C (+or- 2°C), diffuse light (0.1-10 µmol/m².s, natural photoperiod), the water was changed at least once per week.
Dissolved oxygen concentration >80% of the air saturation value.
- Only Zebrafish with 12 days of acclimatisation and mortality <5% within the last 7 days before the study starts were used in the test.
- No disease treatments were administered throughout holding.
- Water used: same water as used during the test.
- Feeding: Trouvit 40/2; MILKVIT, Burgheim; 3 times per week. The amount of food was 4% of the fish body weight per feeding day. The test fish were not fed 24h before the test was started.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 40 - 180 mg CaCO3/L
- Test temperature:
- 21.0 - 21.9°C
- pH:
- 6.88 - 7.64
- Dissolved oxygen:
- > 60% air saturation value (94 - 99%)
- Salinity:
- no data
- Nominal and measured concentrations:
- Nominal concentrations: 0.625 - 1.25 - 2.5 - 5 - 10 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass-aquaria loosely covered by glass tops
- Test volume: 10L per vessel
- Aeration: gentle aeration provided
- No. of organisms per concentration and control: 7
- 1 replicate per test concentration and control
- Fish density in the tanks: <1g fish per liter
- No feeding during test
TEST MEDIUM / WATER PARAMETERS
- Tap water of local origin used for holding. The water was filtered on activated charcoal and aerated for at least 24h to remove chlorine.
- Total hardness: 40 - 180 mg CaCO3/L
- pH value: 6.0 - 8.5
OTHER TEST CONDITIONS
- Photoperiod: natural photoperiod
- Light intensity: 0.1-10 µmol/m².s
TEST CONCENTRATIONS
- Geometrical series with a dilution factor of 2 - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 4.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL = 3.8 - 4.8 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - After 2h, small oily stains of the test item on the surface of all concentrations levels.
- After 96h, the concentration level 5 mg/L showed formation of foam.
- Mean DOC content of the test media at test start: 4.6 mg/L for the concentration 10 mg/L, 3.0 mg/L for the concentration 5 mg/L, 2.1 mg/L for the concentration 2.5 mg/L and 1.8 mg/L for the control.
- Mean DOC content of the test media at test end: 3.6 mg/L for the concentration 10 mg/L, 2.5 mg/L for the concentration 5 mg/L, 4.0 mg/L for the concentration 2.5 mg/L and 3.3 mg/L for the control. - Results with reference substance (positive control):
- not relevant
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- see conclusions
- Conclusions:
- Validity criteria:
- O2 saturation > 60%
- Mortality in the control = 0% - Executive summary:
Acute toxicity of 1-Decanamine, N-decyl, N-methyl to Danio rerio has been investigated through GLP requirements, OECD Guideline 203 and EEC Directive 92/69/EEC Method C.3.
Danio rerio were exposed for 96 hours to a solution of 1-Decanamine, N-decyl, N-methyl
at nominal concentrations of 0.625 - 1.25 - 2.5 - 5 and 10 mg/L.LC 50 - 96h was determined to be of 4.3 mg/L and the NOEC of 2.5 mg/L.
Validity criteria were fulfilled.
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