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EC number: 423-630-1 | CAS number: 62435-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Remarks:
- China National Accreditation Services for Conformity Assessment (CNAS) and proved to be in compliance with CNAS/CL01:2006 'Accreditation Criteria for Testing and Calibration Laboratories
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 423-630-1
- EC Name:
- -
- Cas Number:
- 62435-71-6
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 2-(ethoxymethyl)oxolane
- Details on test material:
- - Clear colourless liquid
- Sample no: ZL0902374
- Soluble in water and plant oil
- Supplied by Thomas Swan & Co,. Ltd. and kept in its original container at room temperature in the Test substance Store Room.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Supplier: Guangdong Medical Laboratory Animal Center [certified animal number SCXK (Guangdong) 2008-0002].
- Number of animals used: 5 male and 5 female
- Number of groups: 2
- Body weight at start of experiment: 180-250g
- Identification of animals: Tags marked with animal group number and treatment detaisl were attached to cages. Each animal was given a unique number.
- Acclimatisation: 5 days prior to the experiment in the test room
- Test Room: In the Center
- Animal house condition: The test facility was an air-conditioned room with 12 hours artificial fluorecent light and 12 hours dark.
- Temp range: 20~25°C
- Humidity Range: 40~70%
- Caging: Stainless steel grid rat cages were used. Autoclaved clean dry corncob was used as the bedding material. Animals were housed in groups by sex in cages, and each cage contained 5 animals at most.
- Water bottle: Each cage was supplied with a polypropylene water bottle with a stainless steel nozzle.
- Sanitation: Bedding material and cages were changed daily.
- Food and Water: Standard pellet feed supplied by Guangdong Medical Laboratory Animal Center and sterile water were provided to the animals.
-Freq. of providing feed and drinking water: Both drinking water and feed were provided ad libitum.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - An area of about 5 x 8cm2 on the back of animals was clipped free of hair. 24 hours later, the intact animals were selected to use. A known weight of the test substance was embrocated onto the hair-free site of the test rats.
- Duration of exposure:
- 24 hours
- Doses:
- One limit dose group (2500mg/kg) and one control group were set. 5 male and 5 female animals were involved in each group.
- No. of animals per sex per dose:
- 5 Male and 5 Female
- Control animals:
- not specified
- Details on study design:
- - An area of about 5 x 8cmE2 on the back of animals was clipped free of hair. 24 hours later, the intact animals were selected to use. A known weight of the test substance was embrocated onto the hair-free site of the test rats. The rats were fasten in the stainless steel shelves for 24 hours, then the test sites were cleaned with warm water. Rats were observed for 14 days after the administration. The rats of control group were treated as the rats of test group but with no test material.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortaility was oberserved in rats of limit dose group and control group throughout the observation period.
- Clinical signs:
- other: No obvious poisoning symptoms were found in animals of test group and control group in 24 hours' administration. in the 14-day observation period, no obvious poisoning symptoms were found in animals of all groups, except for weight loss in a few animals
- Other findings:
- NECROPSY: No major gross abnormalities were found in animals of test group and control group at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Acute dermal LD50 of Ethyl Tetrahydrofurfuryl Ether supplied by Thomas Swan & Co,. Ltd for rst was considered as > 2500 mg/kg.b.w
Based on the guidelines for the Hazard Evaluation of New Chemical Substances, the acute dermal toxicity of Ethyl Tetrahydrofurfuryl Ether is estimated to be non-classified
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