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EC number: 242-419-3
CAS number: 18547-93-8
In the key acute oral toxicity study with
dimethacrylate, the reported LD50 value was greater than 2000 mg/kg bw
Two groups of three female rats were treated with the test item by oral
gavage administration at a dosage of 2000 mg/kg body weight. The test
item was administered according to the body weight of the animals. The
animals were observed on delivery, on inclusion in the study and before
administration for mortality/morbidity and other clinical signs. All
animals were examined for clinical signs several times on the day of
dosing and once daily until the end of the observation period. Their
body weights were recorded on day 1 (prior to the administration) and on
days 8 and 15. All animals were necropsied and examined macroscopically.
All animals survived until the end of the study without showing any
test-item related signs of toxicity. Throughout the 14-day observation
period, the body weight gain of the test animals was within the normal
range of variation for this strain. At necropsy, no treatment-related
macroscopic findings were observed.
Based on the available data for
dimethacrylate, no classification for acute toxicity is required
according to Regulation (EC) No 1272/2008.
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