Registration Dossier
Registration Dossier
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EC number: 220-668-9 | CAS number: 2855-27-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to REACh Regulation (Annex VIII, section 8.5.3. second column) the acute toxicity study by the dermal route dose not need to be conducted as systemic effects in in vivo skin irritation and skin sensitization studies were not observed for TVCH. During the acute toxicty study by the oral route at high doses of 3980 mg/kg and above, transient narcotic effects were observed warranting a classification for specific target organ toxicity following single exposure, category 3 (STOT SE 3). However, significant toxic effects of relevance to human health after single exposure that would warrant a classification for STOT SE 1 or 2 were not observed with TVCH.
Thus, it is concluded that the acute toxicity study by the dermal route can be waived.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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