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EC number: 203-626-4 | CAS number: 108-89-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Cosmetic guideline study with no information on GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Eye and Skin Irritation Induced by Picolines
- Author:
- H. DUTERTRE-CATELLA, N. PHu-LIeH, V. N. HUYEN, L. ÜLIVIER,
R. TRUHAUT, and J.-c. CLAUDE - Year:
- 1 989
- Bibliographic source:
- Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxie Substances
Arch. Toxico!., Supp!. 13, 428-432
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: French Journal Officiel 1984
- Principles of method if other than guideline:
- French official protocol after the method of: Draize JH, Woodard G and Calvery HO, 1944. Methods for the study of irritation and toxicity of stubstances applied topically to the skin and mucous membranes. J. Pharmacol Exp Therap 82:377-390.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylpyridine
- EC Number:
- 203-626-4
- EC Name:
- 4-methylpyridine
- Cas Number:
- 108-89-4
- Molecular formula:
- C6H7N
- IUPAC Name:
- 4-methylpyridine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 6 male New Zealand albino rabbits were obtained from CEGAV, 61350 Saint-Mars-d'Egrenne and weight 2.5 kg at the beginning of the study. They were housed inidvidually in wire mesh cages and fed on a commercial diet with tap water ad libitum. They were kept at least one week for acclimatization prior to testing. Animals were sacrificed after 7 or 14 days.
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Test material (0.1 ml) is instilled into the conjunctival sac and the eye is held closed for 10 seconds. The animals are held in a holding device for 1 hour, and then returned to their cages. Readings are made at 1 hour and also at 1, 2, 3, 4 and 7 days after instillation. Aqueous fluorescein 2%, preferably freshly prepared, is used to inspect the eye, together with a flashlight and ophthalmology UV lamp lens
In this study, histopathological examination of the exposure sites took place on the 7th day. In this study, treatment of the eyes and skin occured in the same animals. Eyes were fixed in 10% neutral buffered formalin and skin in Bouin's solution. Sections of tissues were stained with hematoxilin-eosin-saffron.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- conjunctivae score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- iris score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- cornea opacity score
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 58
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: severe irritation
- Irritant / corrosive response data:
- Data on individual animals is not available, nor is the IOI (the sum of the scores for each animal at the various time points, which provides an indication of individual variation.
For pyridine, the maximum irritation occured at one hour with a score of 43, which is evaluated as an "irritant". It is noted that there was individual variation, with a few rabbits recovering completely while the lesions of others got worse between the first and last reading. Because overall recover is poor, the category of irritation is increased to "severely" in the text. However, this is not defined in the 1982 grading system
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- 4-Methylpyridine was tested for eye irritation in the official French protocol (based on a Draize scale) in rabbit, and found to be "very irritating or severely irritating".
- Executive summary:
The eye irritation of the test item has been tested in accordance with French official protocol after the method of: Draize JH, Woodard G and Calvery HO, 1944.
Test material was instilled into the conjunctival sac of 6 males from New Zealand albino rabbits and was found to be "very irritating or severely irritating".
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