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Diss Factsheets
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EC number: 947-286-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 December 1984 - 14 January 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- the grading scale is different from the OECD guideline (Draize); 3-day observation period; the same animals are tested with different test items
- GLP compliance:
- yes
Test material
- Reference substance name:
- Resinoid of Canarium luzonicum (Burseraceae) obtained from the exudate by benzyl benzoate extraction.
- Molecular formula:
- Not applicable (UVCB)
- IUPAC Name:
- Resinoid of Canarium luzonicum (Burseraceae) obtained from the exudate by benzyl benzoate extraction.
Constituent 1
- Specific details on test material used for the study:
- Extract of elemi gum with benzyl benzoate, containing 30% benzyl benzoate
Name of test material: Elemi resinoid P
Appearance: thick pale yellow jelly
Storage: ambiant temperature
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: commercial supplier
- Age at study initiation: 9-12 weeks
- Weight at study initiation: 1.62-2.34 kg
- Housing: individually in suspended cages with wire mesh floor
- Diet (e.g. ad libitum): pelleted, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 3-4 days
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Remarks:
- 3 or 4 days prior to testing the backs and flanks of rabbits are clipped. The hair is given a final clip about 2h prior to treatment
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 7
- Details on study design:
- Each patch consists of a 25x25 mm, 16-ply gauze pad backed by a 20x30 mm strips of thin polythene and stuck to a 25x75 mm strip of zinc oxide plaster.
Up to 6 patch tests are applied on each animal
Rabbits are immobilised in a canvas body sleeve and placed in a quiet place for the 4-h application period, at the end of which the animals are removed from the body sleeves and the corners of each treatment site marked. Patches are then removed and excess substance wiped from the skin with a damp tissue.
Assessment:
Treatment sites are assessed immediately after removal of the patches and 24, 48 and 72 h after treatment.
Reactions are assessed for erythema, edema, cracking and scaling on a 9-point scale ranging from slight (a) to severe (h). Any other features of responses are described and recorded.
-: no reaction
a: marginal (very slight)
b: slight
c: fairly distinct
d: quite distinct
e: becoming well developped
f: well developped
g: becoming severe
h: severe
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Reversibility:
- other: reversible
- Remarks on result:
- probability of weak irritation
- Other effects:
- No signs of cracking or scaling were observed.
Any other information on results incl. tables
Table 1: Individual scores
Rabbit No |
4 hours |
24 hours |
48 hours |
72 hours |
||||
|
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
1 |
- |
- |
b |
a |
b |
a |
- |
- |
2 |
b |
a |
b |
a |
- |
- |
a |
- |
3 |
b |
a |
b |
a |
a |
- |
a |
a |
4 |
b |
a |
a |
- |
a |
- |
- |
- |
5 |
- |
- |
- |
- |
- |
- |
- |
- |
6 |
b |
a |
- |
- |
a |
- |
- |
- |
7 |
a |
a |
- |
- |
a |
- |
- |
- |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the experimental conditions, only reversible slight signs of edema and erythema, equivalent to maximum score 1 in Draize grading scale, were observed therefore the substance can be considered as slightly irritant and does not require classification according to Regulation EC N° 1272/2008 (CLP) criteria.
- Executive summary:
7 New Zealand White rabbits were applied 0.5 mL of undiluted test item for 4 hours under semi-occlusive conditions. Reactions were recorded immediately, 24, 48 and 72 h after treatment.
Under the experimental conditions, partly reversible slight signs of edema and erythema, equivalent to maximum score 1 in Draize grading scale, were observed therefore the substance can be considered as slightly irritant and does not require classification according to Regulation EC N° 1272/2008 (CLP) criteria.
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