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EC number: 210-288-1 | CAS number: 611-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- There is no short term toxicity data available for this substance. The substance benzophenone, which is the parent molecule for the di hydroxy species 4,4 -dihydroxybenzophenone, is used widely in personal care products and has been evaluated for both toxicology and ecotoxicology. It has ben assessed that in the absence of other spcific data on 4,4 -dihydroxybenzophenone that benzophenone can be used as a suitable surrogate molecule for evaluation of this end point.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- Chinese National Standards:GB/T 27861-2011 (fish)
These methods basically referred to the OECD or ISO standards - Principles of method if other than guideline:
- Aerated tap water was used to prepare a serial concentration of BP or DEET solution. Ten fish were put in a 5000-mL glass beaker with 4000 mL of solution. The experiments lasted 96 h. Each concentration test including cosolvent and blank control groups were designed with three parallel samples. The numbers of the dead individuals were recorded every 24 h.
- GLP compliance:
- not specified
- Remarks:
- Chinese reference material
- Specific details on test material used for the study:
- Analytical purity grade BP was purchased from Sinopharm Chemical Reagent Co. Ltd. (Shanghai, China).
- Details on test solutions:
- Stock solutions were prepared for B. rerio (50.10 mg/L BP and 690.30 mg/L DEET). All stock solutions were set up as 100%; then, a series of solutions at different percentages were made for the test.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- B. rerio (AB strains) were ordered from Nanjing YSY Biotech Company Ltd. (Nanjing, China). The average body length was 2.60 ± 0.20 cm, average body weight was 0.33 ± 0.06 g, and potassium dichromate was used to test the sensitivity of B. rerio before the toxicity experiments. The experiments were carried out at: 25 ± 2 °C, pH 7.0–8.0, 12 h:12 h light–dark cycle
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14.73 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- In a concentration range from 8.00 to 20.00 mg/L, the relationship between the mortality of B. rerio and BP concentration was described by a linear equation:
y = −47.628 + 6.644x, (x: 8.00 mg/L~20.00 mg/L), where x is the BP concentration, and y is the mortality of B. rerio (%).
The acute toxicity of BP to B. rerio was shown as a linear graph in the paper.
The 96-h LC50 of B. rerio for BP was 14.73 mg/L (95% confidence interval: 14.11–15.39 mg/L), and thisvalue was classified as medium-level toxicity - Validity criteria fulfilled:
- yes
- Conclusions:
- According to the acute toxicity results of benzophenone (BP), the 96-h LC50 for B. rerio was 14.73 mg/L, which was judged as medium-level toxicity.
According to the authors of this paper, among all the acute toxicity data of BP registered in AIST-MeRAM, the 96-h LC50 of Oryzias latipes (fish) was 10.00 mg/L, which is a little lower than the results in the present study. There were 10 data about the LC50 of Pimephales promelas (fish), 9 of which were between 14.20 and 15.30 mg/L, which is very close to the 96-h LC50 value (14.73 mg/L) of B. rerio in the present study. These results indicated that the 96-h LC50 of BP tested by B. rerio was reasonable as compared with the results obtained by other species of fish. - Endpoint:
- short-term toxicity to fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Referenceopen allclose all
Description of key information
There is no short term toxicity data available for this substance. The substance benzophenone (BP), which is the parent molecule for the di hydroxy species 4,4 -dihydroxybenzophenone, is used widely in personal care products and has been evaluated for both toxicology and ecotoxicology. It has been assessed that in the absence of other spcific data on 4,4 -dihydroxybenzophenone that benzophenone can be used as a suitable surrogate molecule for evaluation of this end point.
According to the acute toxicity results of benzophenone (BP), the 96-h LC50 for B. rerio was 14.73 mg/L, which was judged as medium-level toxicity.
According to the authors of the reference publication, among all the acute toxicity data of BP registered in AIST-MeRAM, the 96-h LC50 of Oryzias latipes (fish) was 10.00 mg/L, which is a little lower than the results in the present study. There were 10 data about the LC50 of Pimephales promelas (fish), 9 of which were between 14.20 and 15.30 mg/L, which is very close to the 96-h LC50 value (14.73 mg/L) of B. rerio in the present study. These results indicated that the 96-h LC50 of BP tested by B. rerio was reasonable as compared with the results obtained by other species of fish.
Reliable data been published on benzophenone, which is the parent molecule for the substance under test.
There are reliable key study data for daphnia, algae and microorganisms for the susbtance under test (4,4,dihydroxybenzophenone) and it is not thought necessary to carry out further testing on fish for this end point.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 14.73 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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