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EC number: 679-769-5 | CAS number: 2675-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1993-05-18 to 1993-05-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulation, Title 16, Section 1500.41
- GLP compliance:
- yes
Test material
- Reference substance name:
- N,N-diethylprop-2-enamide
- EC Number:
- 679-769-5
- Cas Number:
- 2675-94-7
- Molecular formula:
- C7-H13-N-O
- IUPAC Name:
- N,N-diethylprop-2-enamide
Constituent 1
- Specific details on test material used for the study:
- Batch No.: not specified
Purity: not specified
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfied (U.K.) Ltd., Petersfield, Hampshire, England
- Age at study initiation: approximately 13 to 14 weeks
- Weight at study initiation: 2.9 to 3.3 kg
- Housing: be housed individually in plastic cages with perforated floors
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19
- Humidity (%): 30 to 70
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 hours artificial light in each 24 hours period
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 100 mm x 100 mm
- Type of wrap if used: "Elastoplast " elastic adhesive dressing backed with "Sleek" waterproof strapping.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treament sites were washed with warm water (30 to 40 °C)
OBSERVATION TIME POINTS: on Day 2 (i.e. approximately 30 min after removal of dressings) and on Day 4 (equivalent to 24 and 72 hours after exposure).
SCORING SYSTEM: Draize
- Method of calculation: the numberical scores for erythema and oedema at both 24 and 72 hour readings for both intact and abraded skin sites were added together and divided by 24 to give the primary irritation index (PII)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: abraded skin
- Remarks:
- only scored at 24 h and 72 h, not determined at 48h
- Irritant / corrosive response data:
- Very slight to well-defined erythema with or without very slight to slight oedema was seen at the intact and abraded sites of all six animals at the 24 hours reading. By the 72 hours reading very slight to moderate erythema and oedema was seen in all six animals. Harding of the skin was seen at the abraded site of two animals at the 72 hours reading. Very slight to well-defined erythema with or without very slight to slight oedema was seen at the intact and abraded sites of all six animals at the 24 hours reading. By the 72 hours reading very slight to moderate erythema and oedema was seen in all six animals. Harding of the skin was seen at the abraded site of two animals at the 72 hours reading.
Any other information on results incl. tables
Dermal reaction observed after application of test item
Rabbit number and sex | E=Erythema O=Oedema |
24 hours | 72 hours | ||
intact | abraded | intact | abraded | ||
1939 female | E | 1 | 1 | 1 | 1 |
O | 0 | 0 | 1 | 1 | |
1946 female | E | 2 | 2 | 2 | 2 |
O | 2 | 2 | 2 | 2 | |
1941 male | E | 2 | 2 | 2 | b3 |
O | 2 | 2 | 2 | 3 | |
1942 male | E | 2 | 2 | 2 | b3 |
O | 1 | 2 | 2 | 3 | |
1943 male | E | 2 | 2 | 2 | 3 |
O | 1 | 2 | 2 | 2 | |
1944 female | E | 1 | 2 | 1 | 3 |
O | 0 | 2 | 1 | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- other: classified as a moderate irritant
- Conclusions:
- A single occlusive application of test item to intact and abraded rabbit skin for 24 hours elicited well-defined to moderate dermal reactions and is classified as moderate irritant.
- Executive summary:
The study was performed to assess the skin irritation potential of the test item to the rabbit. The method followed in Code of Federal Regulations, Title 16, Section 1500.41.
Six rabbits were each administered a dermal dose of 0.5 ml of test substance to one intact and one abraded skin site and observed for three days.
A single occlusive application on test item to intact and abraded rabbit skin for 24 hours elicited well-defined to moderate dermal reactions.
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