Registration Dossier
Registration Dossier
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EC number: 200-955-5 | CAS number: 76-37-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- not reported
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mutation to streptomycin resistance in Klebsiella pneumonia
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2,3,3-tetrafluoropropan-1-ol
- EC Number:
- 200-955-5
- EC Name:
- 2,2,3,3-tetrafluoropropan-1-ol
- Cas Number:
- 76-37-9
- Molecular formula:
- C3H4F4O
- IUPAC Name:
- 2,2,3,3-tetrafluoropropan-1-ol
- Test material form:
- not specified
Constituent 1
Method
- Target gene:
- Streptomycin resistance
Species / strain
- Species / strain / cell type:
- other: Klebsiella pneumoniae
- Additional strain / cell type characteristics:
- other: uracil and proline auxotroph
- Metabolic activation:
- not specified
- Test concentrations with justification for top dose:
- not reported
- Vehicle / solvent:
- not reported
- Details on test system and experimental conditions:
- no details reported
- Rationale for test conditions:
- not reported
- Evaluation criteria:
- not reported
- Statistics:
- not reported
Results and discussion
Test results
- Key result
- Species / strain:
- other: Klebsiella pneumoniae
- Metabolic activation:
- not specified
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- not determinable because of methodological limitations
Applicant's summary and conclusion
- Conclusions:
- The reported information is insufficient to conclude on mutagenicity in bacterial systems.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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