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EC number: 231-832-4 | CAS number: 7758-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two toxicity to microorganism studies as-
WoE 2 and WoE 3. - GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2: activated sludge and WoE 3: Escherichia coli
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- WoE 2: 30 mins and WoE 3: 96 hr
- Nominal and measured concentrations:
- WoE 2: Highest tested concentration of 1800 mg/l
WoE 3: no data available - Reference substance (positive control):
- not specified
- Duration:
- 30 min
- Dose descriptor:
- EC0
- Effect conc.:
- 1 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: WoE 2
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 800 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: WoE 2
- Duration:
- 96 h
- Dose descriptor:
- other: growth inhibition threshold
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: WoE 3
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: WoE 3
- Details on results:
- WoE 2:
With proper introduction to adapted biological Purification plants are not disruptions to the dismantling activity of the activated sludge to be expected.
No respiratory inhibition of adapted activated sludge up to to the highest tested concentration of 1800 mg/l. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, the EC50 value can be expected to be >180 mg/l.
- Executive summary:
Data available of the read across chemicals has been reviewed to determine the effect of the test chemical on microorganisms. The studies are as mentioned below:
Toxicity to microorganisms study was carried out. Study was performed in accordance with the ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation) for 30 mins. Activated sludge (adapted) was used as a test inoculum. With proper introduction to adapted biological Purification plants are not disruptions to the dismantling activity of the activated sludge to be expected. No respiratory inhibition of adapted activated sludge up to to the highest tested concentration of 1800 mg/l. Thus, based on effect on total respiration of the test inoculum activated sludge, the 30 mins EC0 and EC50 value was determined to be 1800 and >1800 mg/l, respectively.
Another toxicity to microorganismsstudy was carried out. Study was performed using Escherichia coli as a test organism for a period of 96 hrs. Based on effect on growth inhibition of the test bacteria, growth inhibition threshold value was determined to be 180 mg/l. Thus, based on reviewer judgement, 96 hr EC50 value can be considered as >180 mg/l.
On the basis of the experimental studies of read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, the EC50 value can be expected to be >180 mg/l.
Reference
Description of key information
On the basis of the experimental studies of read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, the EC50 value can be expected to be >180 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 180 mg/L
Additional information
Data available of the read across chemicals has been reviewed to determine the effect of the test chemical on microorganisms. The studies are as mentioned below:
Toxicity to microorganisms study was carried out. Study was performed in accordance with the ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation) for 30 mins. Activated sludge (adapted) was used as a test inoculum. With proper introduction to adapted biological Purification plants are not disruptions to the dismantling activity of the activated sludge to be expected. No respiratory inhibition of adapted activated sludge up to to the highest tested concentration of 1800 mg/l. Thus, based on effect on total respiration of the test inoculum activated sludge, the 30 mins EC0 and EC50 value was determined to be 1800 and >1800 mg/l, respectively.
Another toxicity to microorganisms study was carried out. Study was performed using Escherichia coli as a test organism for a period of 96 hrs. Based on effect on growth inhibition of the test bacteria, growth inhibition threshold value was determined to be 180 mg/l. Thus, based on reviewer judgement, 96 hr EC50 value can be considered as >180 mg/l.
On the basis of the experimental studies of read across chemical and applying the weight of evidence approach and by evaluating the effect of test chemical on test organism, the EC50 value can be expected to be >180 mg/l.
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