Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-476-0 | CAS number: 27469-60-9
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-02-03 to 2017-05-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-[bis(4-fluorophenyl)methyl]piperazine
- EC Number:
- 248-476-0
- EC Name:
- 1-[bis(4-fluorophenyl)methyl]piperazine
- Cas Number:
- 27469-60-9
- Molecular formula:
- C17H18F2N2
- IUPAC Name:
- 1-[bis(4-fluorophenyl)methyl]piperazine
- Test material form:
- solid: particulate/powder
- Details on test material:
- White to light yellow powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: A16FC1793
- Analytical purity: 100.2%
- Expiration date: 08 June 2018 (retest date)
- Storage condition: at room temperature
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.384 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- concentration analysed after centrifugation
- Loading of aqueous phase:
- 2.65 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 9.1 - <= 9.4
- Details on results:
- Preliminary test
The content of test item dissolved in the water sample was 0.505 g/L after two centrifugation steps
Main test
The results for the samples taken at 24, 48 and 72 hours are given in the table in the next section.
The 24-hour measurement was significantly lower than the 48- and 72- hour measurements (maximum difference (MD) > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.
No test item was detected in the pretreated sample from the blank water mixture.
Any other information on results incl. tables
The results for the samples taken at 24, 48 and 72 hours are given in the table underneath.
| Stirring time (hours) | Analysed concentration (g/L) | Mean (g/L) | Maximum Difference (MD) (%) | pH |
| 24 | 0.309 | 0.3841 | 13 | 9.4 |
| 48 | 0.360 | 9.3 | ||
| 72 | 0.408 | 9.1 |
1: Calculated with the 48- and 72-hour measurements.
Applicant's summary and conclusion
- Conclusions:
- The flask method was applied for the determination of the water solubility of JNJ-118781-AAA (T000841).
The water solubility of the test item at 20°C was 0.384 g/L.
The pH of the aqueous samples was 9.1 – 9.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
