Registration Dossier
Registration Dossier
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EC number: 281-638-9 | CAS number: 84000-82-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative Database
- Title:
- Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- other: Authoritative Database
- Title:
- Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- Gestis Substance Database ,2017
- Reference Type:
- publication
- Title:
- Acute toxicity of various solvents in the mouse and rat. LD50 of ethanol, diethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2- propanediol and Tween 20.
- Author:
- Bartsch W, Sponer G, Dietmann K, Fuchs G
- Year:
- 1 976
- Bibliographic source:
- Drug discovery. 1581-3: 26 (8); 1976
- Reference Type:
- other: Authoritative Database
- Title:
- Acute oral toxicity study of 1-Methyl-2-pyrrolidinone (872-50-4) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of 1-Methyl-2-pyrrolidinone (872-50-4) on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data available
- Limit test:
- no
Test material
- Reference substance name:
- 1-mehyl-2-pyrrolodone
- Cas Number:
- 872-50-4
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 1-mehyl-2-pyrrolodone
- Details on test material:
- - Name of test material (IUPAC name): 1-Methyl-2-pyrrolidinone
- Common name: 1-Methylpyrrolidone
- Molecular formula: C5H9NO
- Molecular weight: 99.1321 g/mol
- Smiles notation: C1(=O)N(CCC1)C
- InChl: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Methylpyrrolidone
- Molecular formula :C5H9NO
- Molecular weight :99.1321 g/mol
- Substance type:organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 3914 mg/kg bw
- No. of animals per sex per dose:
- Total: 10 animals
3914 mg/kg bw : 5 females and 5 males - Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 914 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% Mortality was observed in treated rats at 3941 mg/kg bw
- Mortality:
- 50% Mortality was observed in treated rats at 3941 mg/kg bw
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 3914 mg/kg bw ,when groups of 10 (5 males,5 females) rats were treated with 1-Methyl-2-pyrrolidinone (872-50-4) orally.
- Executive summary:
Acute oral toxicity study was done in groups of 10 (5 males,5 females) rats using test material 1-Methyl-2-pyrrolidinone(872-50-4) .50% Mortality was observed at dose 3914 mg/kg bw. Hence,LD50 value was considered to be 3914 mg/kg bw,when rats were treated with 1-Methyl-2-pyrrolidinone(872-50-4)orally.
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