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EC number: 201-851-2 | CAS number: 88-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance is considered to be not irritating to the skin but induces irreversible effects on the eye
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to BASF-internal standard. Two rabbits (1 male, 1 female) were dermally exposed to the test substance followed by a 8 day observation period. Test areas where the back and the ear of the rabbit.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Weight of female animal: 2.93 kg
- Weight of male animal: 3.4 kg - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Amount / concentration applied:
- about 1 g of a 50 % aqueous preparation
- Duration of treatment / exposure:
- 1, 5, and 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: The back of the animals
- Application area: 2.5 x 2.5 cm:
- Type of wrap if used: Cotton pad for the back of the animals
REMOVAL OF TEST SUBSTANCE
- Washing: Lutrol 50%
- Time after start of exposure: 20 hours - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: no effects were observed 8 days after 20 hours exposure
- Irritant / corrosive response data:
- Also no effects observed after 1, 5, and 15 minute and 20 hours exposure.
- Other effects:
- None
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to BASF-internal standard. Two rabbits (1 male, 1 female) were exposed to the undiluted test substance in the eye followed by a 8 day observation period.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- - Weight of female animal: 2.76 kg
- Weight of male animal: 2.96 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of the same animal
- Amount / concentration applied:
- ca. 50 mg
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- The test substance was not washed out.
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- animal 1 and animal 2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: control eye also showed conjuctiva effects up to 8 days after substance application
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Remarks:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- Blood was observed in the exposed eye of animal one at 1 hour after exposure, but was absent thereafter
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
Reference
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
To assess the skin irritating potential of the test substance, two rabbits (1 male, 1 female) were dermally exposed to the test substance for 20 hours followed by a 8 day observation period. No effects were observed on the exposed areas on the back of both animals. No additional effects were reported. Based on these results the test substance is considered to be not irritating.
Eye irritation / corrosion
To assess the eye irritating potential of the test substance, two rabbits (1 male, 1 female) were exposed to the undiluted test substance in the eye followed by a 8 day observation period and effects were determined 24, 48, 72 hours and 8 days after exposure. Exposure resulted in slight conjunctival redness in both animals after 24 hours (score = 1). This effect was in one of the animals not fully reversible within 8 days. However, it has to be noted that the control eye, which was terated with talcum, also showed conjuctival redness after 24 h and 8 days, indicating that the irreversibility of conjunctival effects should not be considered as classification criteria. One animal showed slight (score = 1) and one animal showed marked chemosis (score = 2) after 24 hours. While chemosis disappeared in the first animal at 48 h, chemosis was still observed at 48 and 72 h in the second animals, but was then absent at day 8 (fully reversible in both animals). Slight corneal opacity was visible in the first animal at 24 h, but was reversible by 48 h. In contrast, marked corneal opacity (score 2) was observed up to 48 h and was the still present as slight corneal opacity (score 1) at 72. This effect was not reversibel by day 8.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the absence of effects after skin exposure, classification for skin irritation / corrosion is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Irreversible effects on corneal opacity were observed in one animal. Since the observation time was only 8 days and it cannot be conclusively shown that these effects will be reversible after 21 days, as a worst case assumption the test substance is classified as H318, Eye category 1 in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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