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EC number: 813-543-0 | CAS number: 73984-93-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- EC Number:
- 813-543-0
- Cas Number:
- 73984-93-7
- Molecular formula:
- C14H26N2S4
- IUPAC Name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Age at study initiation: not reported
- Weight at study initiation: 264 to 284g (males) and 169 to 182g (females)
- Housing: individually in wire-mesh cages
- Diet (e.g. ad libitum): Purina laboratory chow was available ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): during the 4 h exposure period the temperature in the exposure chamber was 27°C
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
IN-LIFE DATES:
From: 15 Dec 1978 To: 29 Dec 1978
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapours of the compound were generated by passing air at the rate of 10 L/min through a round bottom flask containing the compound. The flask was placed in a heating jacket heated to 93°C. The vapours emerging from the flask were introduced into the exposure chamber without dilution. The temperature within the exposure chamber was approximately 27° C. The rats were thus exposed to an atmosphere essentially saturated with vapours of the test material. The concentration of the vapour (0.62 mg/L) in the chamber atmosphere was calculated from the ratio of the total weight loss of the material in the flask after the exposure (1.49 grams) to the total volume of air passing through the flask during the 4 hour period (2400 litres).
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- One exposure level of 0.62 mg/L was used
- No. of animals per sex per dose:
- 5 males and 5 females were used
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed twice daily during the 14 day observation period and body weights were performed at Day 0 (prior to exposure), 1, 3, 5 ,7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.62 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occured during the study
- Clinical signs:
- other: The immediate response of the rats to the experimental atmosphere was an increase of activity in preening. After several minutes of exposure this activity decreased. The rats appeared normal during the 4 hour exposure and throughout the 14 day observati
- Body weight:
- No effect on body weight was noted during the study, refer to table below.
- Gross pathology:
- No findings noted
Any other information on results incl. tables
Animal No. |
Body weight (g) |
|||||
Day 0 |
Day 1 |
Day 3 |
Day 5 |
Day 7 |
Day 14 |
|
M9356 M9357 M9358 M9359 M9360 |
278 282 276 264 284 |
280 283 275 259 278 |
286 280 277 260 280 |
289 277 279 259 280 |
286 283 285 265 284 |
288 287 296 275 284 |
F9361 F9362 F9363 F9364 F9365 |
182 172 177 178 169 |
182 168 173 180 169 |
180 167 173 180 168 |
177 167 168 175 165 |
182 168 171 178 168 |
182 174 170 178 169 |
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Executive summary:
An acute inhalation study was conducted using a similar procedure to that described in the current OECD Guideline 403.
The test material (CAS No. 50530 -43 -3) was administered at 0.62 mg/L by inhalation for 4 h to five male and five female rats. The rats were observed for 14 days after test material administration. No mortalities occurred during the study. No gross pathologic alterations were noted among the animals.
The acute inhalation median lethal dose (LD50) was estimated to be greater than 0.62 mg/L.
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