Registration Dossier
Registration Dossier
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EC number: 276-067-7 | CAS number: 71839-81-1
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity was determined in male albino rats. The LD50 was above 5000 mg/kg body weight. No adverse findings were reported.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: poor reporting with regard to method and sample tested
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Remarks:
- pre- dates guideline
- Principles of method if other than guideline:
- no details reported
- GLP compliance:
- no
- Remarks:
- pre-dates GLP regulation
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- no data
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 was > 5000 mg/kg bw after single oral administration of the test item to male rats.
- Executive summary:
Acute oral toxicity was determined in male albino rats. The LD50 was above 5000 mg/kg body weight. No adverse findings were reported.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- reliable with restriction
early study before GLP regulatioon and Guidelines
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
no classification
The LD50 was above 5000 mg/kg body weight. No adverse findings were reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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