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Diss Factsheets
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EC number: 204-588-1 | CAS number: 122-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was not irritating to the skin.
The test substance was corrosive to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal method
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- An application site of 2.5x2.5 was covered with the liquid.
- Duration of treatment / exposure:
- - back: 1, 5, 15 min and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2 per exposure duration
- Details on study design:
- TEST SITE
- Area of exposure: back - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: 20 hours exposure
- Irritant / corrosive response data:
- - No effects observed in animals exposed for 1, 5 or 15 minutes, on the back.
- Questionable redness observed in one animal exposed for 20 h on the back. - Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline study, non-GLP, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard: Two Vienna White rabbits were subjected to the test substance for 24 hours and observed for 8 days.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: saline treated eye of the same animal
- Amount / concentration applied:
- 1 x 50 mm3 = 0.05 mL
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- - 1 hour after exposure: slight redness, marked edema, and marked opacity was observed
- 24 hours after exposure: marked redness, marked edema, and white nictitating membrane was observed
- 8 days after exposure: slight redness, slight edema, marked opacity and slight scarring was observed - Interpretation of results:
- corrosive
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
Two studies are available in which the potential to cause irritation/corrosion to the skin was evaluated. In the first study (BASF 1967) two Vienna White rabbits were treated for 1 minute, 5 minutes, 15 minutes, and 20 hours, respectively, with the test substance under occlusive conditions. Animals were observed for 8 days. No irritating effects were observed in animals exposed to 1, 5, or 15 minutes. Questionable redness was observed in one animal exposed for 20 hours. It was concluded that the test substance was not irritating to the skin. In the second study (Smyth 1962) five albino rabbits were treated 24 hours with the test substance, under open conditions. Very slight irritating effects were observed.
Eye irritation
Two studies are available in which the potential to cause damage to the eye was assessed. In the first study (BASF 1967) two Vienna White rabbits were subjected to the test substance (0.05 mL). Slight redness, marked edema, and marked opacity was observed 1 hour after exposure. Marked redness, marked edema, and white nictitating membrane was observed 24 hours after exposure. Eight days after exposure slight scarring was observed. In the second study (Smyth 1962) corneal injury was observed in rabbits exposed to test substance.
Justification for selection of skin irritation / corrosion endpoint:
Two skin irritation/corrosion studies are available in which the potential to cause irritation/corrosion to the skin was evaluated. The study which was performed most similar to OECD 404 study has been selected as key study.
Justification for selection of eye irritation endpoint:
Two eye irritation studies are available in which the potential to cause damage to the eye was evaluated. The study containing information about exposure duration and the amount of animals used has been selected as key study.
Effects on eye irritation: corrosive
Justification for classification or non-classification
Only questionable to very slight irritating effects were observed in animals exposed for 20 hours or higher. Based on this classification for skin irritation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Based on the corrosive eye effects observed 2-anilinoethanol has to be classified as Eye damage 1: H318: Causes serious eye damage in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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