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Diss Factsheets
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EC number: 283-815-6 | CAS number: 84731-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Effects on fertility
Description of key information
A dermal reproductive toxicity screening study in rats was conducted according to OECD 422 and no adverse effects were seen in any of the reproductive/developmental parameters examined at any dose.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 089.75 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
There are no data available for lithium isooctadecanoate. However, data on fatty acids C18 (unsaturated) lithium salts are considered to be appropriate for read across on the basis that the two substances have common structures of a lithium salt of C18 fatty acids. Lithium isooctadecanoate has a single methyl branch while fatty acids C18 (unsaturated) lithium salts contains unsaturated carbon-carbon double bonds. See IUCLID section 13 for read across justification.
Fatty acids C18 (unsaturated) lithium salts is a UVCB substance consisting of C18 fatty acids with a range of degrees of unsaturation. Although a molecular weight has not been specified, as a lithium salt of C18 fatty acids, the molecular weight is expected to be comparable to that of lithium isooctadecanoate, varying by only a few hydrogens. Therefore, no calculations have been applied to convert the toxicity values which have been read across between the substances.
A key toxicity and reproductive toxicity screen, using the OECD 422 study design, was conducted in rats on fatty acids C18 (unsaturated) lithium salts via dermal administration. The test material was administered at dose levels of 0, 100, 300 and 1000 mg/kg/day nominal, equating to 111.25, 345 and 1089.75 mg/kg/day by analysis, and were based on local dermal effects from a dose range finding study. There were no treatment-related effects at any dose level on any of the reproductive parameters evaluated in this study, or in any of the developmental parameters evaluated. Based on these data, the NOAEL for reproductive and developmental toxicity was 1089.75 mg/kg/day. The lack of reproductive and developmental toxicity when C18 (unsaturated) lithium salts was administered to rats can be read across to lithium isooctadecanoate, and no classification for this endpoint is required.
A dermal reproductive toxicity screening study in rats was conducted according to OECD 422 and no adverse effects were seen in any of the reproductive parameters examined at any dose. This screening study provides relevant experimental data on this endpoint. The tested substance is appropriate for read across to lithium isooctadecanoate.
Effects on developmental toxicity
Description of key information
A dermal reproductive toxicity screening study in rats was conducted according to OECD 422 and no adverse effects were seen in any of the reproductive/developmental parameters examined at any dose.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 089.75 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
There are no data available for lithium isooctadecanoate. However, data on fatty acids C18 (unsaturated) lithium salts are considered to be appropriate for read across on the basis that the two substances have common structures of a lithium salt of C18 fatty acids. Lithium isooctadecanoate has a single methyl branch while fatty acids C18 (unsaturated) lithium salts contains unsaturated carbon-carbon double bonds. See IUCLID section 13 for read across justification.
Fatty acids C18 (unsaturated) lithium salts is a UVCB substance consisting of C18 fatty acids with a range of degrees of unsaturation. Although a molecular weight has not been specified, as a lithium salt of C18 fatty acids, the molecular weight is expected to be comparable to that of lithium isooctadecanoate, varying by only a few hydrogens. Therefore, no calculations have been applied to convert the toxicity values which have been read across between the substances.
A key toxicity and reproductive toxicity screen, using the OECD 422 study design, was conducted in rats on fatty acids C18 (unsaturated) lithium salts via dermal administration. The test material was administered at dose levels of 0, 100, 300 and 1000 mg/kg/day nominal, equating to 111.25, 345 and 1089.75 mg/kg/day by analysis, and were based on local dermal effects from a dose range finding study. There were no treatment-related effects at any dose level on any of the reproductive parameters evaluated in this study, or in any of the developmental parameters evaluated. Based on these data, the NOAEL for reproductive and developmental toxicity was 1089.75 mg/kg/day.
The lack of developmental toxicity when C18 (unsaturated) lithium salts was administered to rats can be read across to lithium isooctadecanoate, and no classification for this endpoint is required. This study provides relevant experimental data on this endpoint and the data on the tested substance can be read across to lithium isooctadecanoate.
Justification for classification or non-classification
Not classified. No adverse reproductive or developmental toxicity effects observed.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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