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Diss Factsheets
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EC number: 210-535-3 | CAS number: 617-86-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No sensitisation data are
available for the registered substance. Data are available for the
structural analogue, tetramethylsilane (CAS 75-76-3), from a skin
sensitisation study, conducted in accordance with OECD 406 (Buehler
method) and in compliance with GLP.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There are no measured data available to assess the skin sensitisation potential of triethylsilane. Therefore data for the structural analogue substance tetramethylsilane (CAS 75-76-3) has been used to assess its skin sensitisation potential.
Tetramethylsilane was not sensitising (Hüls, 1998) when tested in the guinea-pig Buehler assay (OECD 406). Undiluted test substance was applied to 20 animals in both the induction and challenge phases. No irritation was observed in the preliminary irritation test or in the induction or challenge phases, and no skin reactions were observed at challenge. Historical positive controls demonstrated the sensitivity of the test and concurrent negative controls showed no skin reactions.
To reduce animal testing REACH recommends to make use of a read-across approach where appropriate based on the high accordance in properties relevant for the specific endpoint. In the case of sensitisation, the relevant properties are physicochemical properties and structural similarity. In the following paragraphs the proposed read-across from tetramethylsilane to trimethylsilane is discussed.
Read-across hypothesis
The hypothesis is that source and target substances have similar toxicological properties because they are structurally similar and have similar physicochemical properties. The substances are hydrolytically stable (triethylsilane and tetramethylsilane have half-lives in water of days) so reaction products do not need to be considered for the human health hazard assessment of these substances.
See Section 'repeated dose toxicity' for further justification of the read-across.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are no skin sensitisation data on triethylsilane, so good quality data on the structurally-related substance, tetramethylsilane have been used for read-across.
In a key guinea pig skin sensitisation study (Buehler test), conducted in compliance with GLP and according to OECD TG 406, tetramethylsilane was found to be a non-sensitiser. No irritation was observed so undiluted test substance was used in both the induction and challenge phases. The sensitisation index was calculated to be 0% for the test group following challenge. Appropriate positive and solvent controls were included and gave expected results.
In the absence of measured data for triethylsilane, it is considered appropriate to use this result in support of the skin sensitisation endpoint. The both registered substance and read-across substance are moderately lipophilic (log Kow 3.6 and 2.7 respectively) for which dermal uptake is favourable. The substances are hydrolytically stable (triethylsilane and tetramethylsilane have half-lives in water of days) so reaction products do not need to be considered for the human health hazard assessment of these substances and read-across based on similarity of parent is appropriate.
Justification for classification or non-classification
Based on a reliable in vivo study on tetramethylsilane, triethylsilane is not classified as a skin sensitiser according to Regulation (EC) No 1272/2008.
There are no data to suggest that triethylsilane is a respiratory sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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