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EC number: 226-033-2 | CAS number: 5235-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One valid acute freshwater fish study was available for 4-(3-(1-naphthylamino)propyl)morpholine. The study was a static, 96-hour exposure with the fathead minnow, Pimephales promelas, and was conducted according to OECD TG 203. This study was assigned a Klimisch score of 2 based on the lack of analytical confirmation of test concentrations used in the study. The test was performed under static conditions with five concentrations, a dilution water control and a solvent control (0.1 ml/L dimethylformamide) at a temperature of 22 ± 1 °C. The reported 96-hour LC50 value was 4.8 mg/L based on nominal concentrations. The 95% confidence intervals for the LC50 were 4.2 – 5.4 mg/L. The 96-hour NOEC value was 2.2 mg/L.
One static acute toxicity test with Daphnia magna was available for 4-(3-(1-naphthylamino)propyl) morpholine. This study was assigned a Klimisch score of 2 based on the lack of analytical measures of test solution concentrations. The 48-hour EC50 value (based on immobility) was reported as 5.1 mg 4-(3-(1-naphthylamino)propyl) morpholine/L with a 95% confidence interval of 4.4 - 6.0 mg/L. This value was based on initial nominal concentrations. Thus, the key parameter for the acute invertebrate endpoint was the EC50 value of 5.1 mg/L.
One static toxicity study with the green algae, Selenastrum capricornutum,was available for review and was found to be of good quality and reliable for use in the risk assessment process (Klimisch score = 2). The Klimisch score for this study was 2 due to the lack of analytical confirmation of test concentrations in this study. This study measured both growth rate (r) and biomass as indicators of growth inhibition over 72 hours of exposure to 4-(3-(1-naphthylamino)propyl) morpholine. Under the conditions of the study, the 72-hour no observed effect concentration was 0.63 mg 4-(3-(1-naphthylamino)propyl) morpholine /L. The 72-hour EC50 was 1.0 mg/L when calculated using the number of cells/ml and 2.6 mg/L when calculated using the average specific growth rate. The 72-hour EC50 based on growth rate is the preferred parameter for summarizing toxicity to aquatic algae, therefore, this value was selected as the key value for this endpoint.
Of these aquatic toxicity values, the 72-hour ErC50 of 2.6 mg/L for growth inhibition in the algae was the lowest value reported, and this data point was used in the development of the PNECaqua.
Additional information
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