Registration Dossier
Registration Dossier
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EC number: 282-162-4 | CAS number: 84100-84-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 0.442 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 3.9
- Details on results:
- As the pH-value is 3.9 for all three measurements it can also be set to 3.9 for the mean value.
As the relative standard deviation between the single determinations is < 15 % the validity criteria have been met. - Conclusions:
- The water solubility of 2,3,3-trimethyl-3H-indole-5-carboxylic acid is 0.442 g/L.
- Executive summary:
The water solubility of the test item 2,3,3-trimethyl-3H-indole-5-carboxylic acid in demineralized water was determined with the flask method at 20 °C according to OECD TG 105.
A quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and the sample is kept in the temperature controlled water bath for another 24 h.
The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection. No pH-value is reported. As the pH-value is 3.9 for all three measurements it can also be set to 3.9 for the mean value. The water solubility of 2,3,3-trimethyl-3H-indole-5-carboxylic acid is 0.442 g/L at 20 °C.
Reference
Results of single determinations and mean value
| Flask A | Flask B | Flask C | Mean value | |
| conc. test item | 0.4555 g/L | 0.4603 g/L | 0.4104 g/L | 0.442 g/L |
| pH-value | 3.9 | 3.9 | 3.9 |
Description of key information
The water solubility of the test item 2,3,3-trimethyl-3H-indole-5-carboxylic acid in demineralized water was determined with the flask method at 20 °C according to OECD TG 105 as 0.442 g/L at 20 °C. No pH-value is reported.
Key value for chemical safety assessment
- Water solubility:
- 0.442 g/L
- at the temperature of:
- 20 °C
Additional information
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