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EC number: 413-060-1 | CAS number: 19186-97-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity
Acute dermal toxicity
Acute inhalation toxicity
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1.81 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral, inhalation and dermal toxicity studies were performed in male and female rats with FR-370.
Acute Oral toxicity: No mortalities were observed in either sex following oral administration of 5000 mg/kg. All rats gained weight during the study. No gross internal lesions were noted in any animal at necropsy.
The only clinical signs noted were chromorhinorrhea, diarrhea, chromodacryorrhea and abdominogenital staining. These symptoms appeared during the first 3 -6 hours after dosing and vanished afterwards.
The oral LD50 of the test material is judged to be greater than 5000 mg/kg to both male and female rats. Under the conditions of the study test material was classified as practically non-toxic by oral administration.
Acute Dermal toxicity: No mortalities were observed in either sexes following dermal application of 2000 mg/kg of FR-370.
No signs of systemic toxicity were noted during clinical observations in both studies?? No abnormalities were noted during necropsy in both studies. The only clinical signs noted were chromodacryorrhea, chromorhinorrhea and diarrhea shortly after dosing. All rats recovered by study day 3 and remained healthy until termination.
The oral LD50 of the test material was determined to be greater than 2000 mg/kg to both male and female rats. Under the conditions of the study test material was classified as non-toxic by dermal application.
Acute Inhalation toxicity: No mortality was observed during 14 days after a single exposure for 4 hours to 1.8 mg/l FR-370 (maximum attainable concentration). There were no significant clinical signs noted during or after the exposure to the test material.
A few non-significant clinical signs were noted during the exposure,
upon removal from the chamber and at
one hour post-exposure including abdominogenital staining,
chromorhinorrhea, dust on fur, lacrimation and squinting eyes.
All animals recovered by study day 1 and remained healthy through study
termination. All animals gained weight by termination on day 14. There
were no gross internal lesions noted in any animal at necropsy.
The LC50 was determined to be 1.81 mg/l (maximum attainable
concentration). Under the condition of this test the test item was
classified as non-toxic by inhalation.
FR-370 is not classified for acute oral toxicity or acute inhalation toxicity or acute dermal toxicity.
Justification for classification or non-classification
Based on the experimental results and according to the EEC criteria for classification and labelling requirements for dangerous substances and preparations (Guidelines in Commission Directive 93/21/EEC, 27th April 1993), FR-370 does not have to be classified and has no obligatory labelling requirement for acute toxicity .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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