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Diss Factsheets
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EC number: 214-874-8 | CAS number: 1204-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Trimellitic anhydride mono-chloride (TMAC, target substance) is unstable in the presence of moisture and undergoes rapid hydrolysis to trimellitic acid (TMLA) (Lord and Cooper, 1992). The hydrolysis of TMAC was virtually instantaneous at 40°C and similarly fast hydrolysis of trimellitic anhydride (TMA) would also be anticipated in production and manufacturing waste waters, with complete conversion to trimellitic acid (TMLA) occurring even before reaching waste water treatment facilities.In view of its rapid hydrolysis, it is not technically possible to determine the aqueous solubility limit of the parent anhydride.
A number of reliable studies address the aquatic toxicity of trimellitic anhydride (TMA,source substance). In these studies (Knackeret al., 1992, 1993a & b; Lebertz, 1991a & b) trimellitic anhydride was first treated with aqueous NaOH solution,to convert the acid anhydride (TMA) to the sodium salt(s) of trimellitic acid (TMLA), and exposure in these studies was consequently to sodium trimellitate (following neutralisation of excess alkali).
No toxicity was observed under these conditions (trimellitic anhydride : TMA) :
Acute toxicity to fish - Golden orfe (L. idus melanotus) 96 hour LC0 (static):>957 mg TMA-equiv/L, 96 hour NOEC≥957 mg TMA-equiv/L;
Acute daphnia inhibition -D. magna 48 hour EC50 (static):>792 mg TMA-equiv/L, 48 hour NOEC≥792 mg TMA-equiv/L;
Algal growth inhibition -D. subspicatus 72 hour ErC50:>739 mg TMA-equiv/L, 72 hour NOEC≥739 mg TMA-equiv/L.
All these endpoints are mean measured values and represent the highest concentration applied.
Toxicity to aquatic microorganisms: 3 hour EC50, based on inhibition of respiration of activated sludge, was between 100 and 500 mg/L. Inhibition, relative to the untreated control, was observed at concentrations≥500 mg/L and the NOEC was 100 mg/L.
In conclusion, trimellitic anhydride mono-chloride (TMAC) exhibit very low toxicity to fish, aquatic invertebrates, unicellular algae and to aquatic microorganisms including biological waste water treatment processes based on results obtained on trimellitic anhydride (TMA) (and more environmentally relevant trimellitic acid, TMLA) using read across.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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