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Diss Factsheets
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EC number: 695-022-6 | CAS number: 473278-76-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The criteria given in the “Guidance on information requirements and chemical safety assessment, chapter R.11: PBT Assessment” (ECHA, 2017) are used to decide if the substance fulfils the PBT or vPvB criteria.
Persistence Assessment
The test substance is considered to be not readily biodegradable according to OECD criteria. However the substance was degraded in soil under aerobic conditions. The calculated half-lives ranged between 2.7 and 14.7 days under the chosen test conditions, which correspond to temperature corrected DT50 values of 5.9 – 32.1 days at 12 °C (average environmental temperature in Europe). Therefore, the substance is not expected to have a potential for accumulation in the environment.
Bioaccumulation Assessment
The partition coefficient log Pow = 1.9 was determined at pH 2.0 and 25 °C. Based on the the measured partition coefficient of the unionized form at pH 2 and the pKa of 3.2 of the substance following partition coefficients for the (partly) dissociated form are estimated:
log D (pH 4): ca. 1.0
log D (pH 7): ca. -1.9
log D (pH 9): ca. -3.9
The log Kow and all Log D values for the dissociated form are below the treshold value of 4.5.
Therefore, the substance is not expected to have a potential for bioaccumulation.
Toxicity Assessment
Based on the available data 2-{2-chloro-4-mesyl-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione is considered to be toxic. Ecotoxicology studies show the substance to exhibit neither chronic effects on aquatic organisms at or below 0.01 mg/L nor are acute effect values below 0.01 mg/L. However, 2-{2-chloro-4-mesyl-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione is classified for specific target organ toxicity as STOT RE 1 (oral route) and STOT RE 2 (dermal route). The criteria for “T” based on mammalian effects are therefore met. Thus, the criteria set out in Annex XIII of Regulation (EC) No. 1907/2006 are met and the substance is considered to be T.
In conclusion, the substance is not PBT/vPvB
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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