Registration Dossier
Registration Dossier
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EC number: 247-063-2 | CAS number: 25513-64-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
No examples of SN1 or SN2-type amine hydrolyses (or solvolyses) have been reported in textbooks or encyclopedias of chemistry. Indeed, such processes would be expected to be endergonic by 4-5 kcal/mol (Keq << 10-3 M). Though, if the rate constant were relevant then it should be possible to observe hydrolysis at low concentrations. However, the need for patented catalysts indicates that the reaction is very slow with common catalysts like acids and bases even at elevated temperatures. Therefore, it can be concluded that amine hydroylsis is negligible under environmental conditions.
Key value for chemical safety assessment
Additional information
(1) The reactivities of amines towards water are similar.
(2) Hydrolysis of amines is endergonic and has no relevance in synthetic organic chemistry.
(3) An experimental study of amine hydrolysis should be technically feasible at moderate to low concentrations.
(4) Amine hydrolysis has no relevant rate at environmental temperatures and pH values.
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