Registration Dossier
Registration Dossier
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EC number: 241-881-3 | CAS number: 17955-88-3
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (28-day): 813 mg/kg dry weight, mortality, Folsomia candida, measured
IC50 (28-day): 767 mg/kg dry weight reproduction, Folsomia candida, measured
NOEC (28-day): 377 mg/kg dry weight mortality and reproduction, Folsomia candida, measured
Key value for chemical safety assessment
Additional information
There are no data describing the long-term toxicity of the registered substance to terrestrial arthropods. However, data are available for the siloxane decamethylcyclopentasiloxane (D5, CAS: 541-02-6).
A 28-day LC50 value of 813 mg/kg dry weight and a 28-day IC50 value of 767 mg/kg dry weight have been determined for the effects of the test substance D5, on mortality and reproduction of Folsomia candida. A NOEC of 377 mg/kg dry weight has been determined by the reviewer on the basis of a visual examination of the data for both mortality and reproduction (Velicogna et al., 2011).
An OECD TG 222 earthworm reproduction study is planned for the registered substance. The earthworm is the standard organism for soil macroorganisms and there is no indication that arthropods would be any more susceptible. Read-across of the terrestrial toxicity data for D5 is considered to be suitable to derive an interim hazard and risk assessment under REACH for the registration substance.
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